丝裂原活化蛋白激酶信号通路在寻常型银屑病发病机制中的研究进展

Research progress of mitogen activated protein kinase signaling pathway in pathogenesis of psoriasis vulgaris

寻常型银屑病的主要组织病理学特征为表皮增殖、真皮炎症细胞浸润、新生血管生成和Munro’s微脓肿的形成,其机制与相关信号通路有着密切关系。丝裂原活化蛋白激酶(MAPK)信号通路的上游信号分子如miRNA、细胞因子等的异常表达导致下游信号分子的异常激活在银屑病的发病中有着重要作用,且有望成为新的干预靶点。本研究就MAPK信号通路在寻常型银屑病发病机制中的研究进展进行综述,为药物研发、精准治疗提供参考。

Main histopathological features of psoriasis vulgaris are epidermal proliferation,dermal inflammatory cell infiltration,neovascularization and the formation of Munro’s microabscesses,and its mechanism is closely related to the related signal pathways.Abnormal expression of upstream signal molecules such as miRNA and cytokines of mitogen activated protein kinase(MAPK)signal pathway leads to abnormal activation of downstream signal molecules,which plays an important role in the pathogenesis of psoriasis,and is expected to become a new intervention target.The article reviewed the research progress of MAPK signaling pathway in the pathogenesis of psoriasis vulgaris,so as to provide reference for drug development and precision treatment.