基于中医传承辅助平台的吴生元教授治疗骨关节炎的用药规律分析

Analysis on the Medication Rule of Professor Wu Shengyuan in the Treatment of Osteoarthritis Based on the Auxiliary Platform of Traditional Chinese Medicine

目的通过总结吴生元教授辨治骨关节炎的临床经验及用药特点,分析挖掘骨关节炎的用药规律,为临床治疗骨关节炎及新药开发研究提供借鉴。方法采集就诊于吴生元教授门诊骨关节炎患者处方,双人校对审核录入“中医传承辅助平台(V2.5)”,使用药物四气、五味、归经及用药频次统计组方规律,使用关联规则分析、聚类分析、无监督熵聚类、复杂系统熵聚类等数据分析挖掘方法等进行药物组合分析。结果筛选处方395张,出现频次大于10的高频药物46味,温、甘性味药物最为常用,归脾、肺、肝、肾四经的药物最多。结论吴生元教授治疗骨关节炎用药强调“调补中焦”和“甘温补虚”;在此基础上辨证选用,以病为核心、以症为辅助治疗骨关节炎,形成独特诊疗经验。

Objective By summing up Professor Wu Shengyuan’s clinical experience and drug use characteristics in the treatment of osteoarthritis,we analyzed and explored the drug use law of osteoarthritis,providing reference for clinical treatment of osteoarthritis and the development and research of new drugs.Methods Collecting the prescriptions of osteoarthritis patients in the outpatient clinic of professor Wu Shengyuan,then double proofreading was entered into the"Auxiliary platform of inheritance of traditional Chinese medicine(V2.5)",and the frequency of four qi,five flavors and economic use of drugs were used to analyze the combination of drugs by using data analysis and mining methods such as association rule analysis,cluster analysis,unsupervised entropy clustering,complex system entropy clustering,and so on.Results 395 prescriptions were selected and 46 high-frequency drugs with a frequency of more than 10 were selected.Warm and sweet drugs were the most commonly used,and the drugs belonging to the four meridians of spleen,lung,liver and kidney were the most used.Conclusion Professor Wu Shengyuan emphasizes"regulating and tonifying Zhongjiao"and"using sweet and warm drugs to tonify deficiency"in the treatment of osteoarthritis.On this basis,he dialectically chooses the disease as the core and the symptoms as the auxiliary treatment of osteoarthritis,forming a unique experience in diagnosis and treatment.