血常规中炎症指标与衰弱及衰弱前期的关系

Relationships of inflammatory indexes with frailty and early stage of frailty

目的探讨临床血常规中炎症指标与衰弱及衰弱前期的关联性。方法采用横断面调查方法对2021年3月—2021年11月在南京鼓楼医院老年医学科住院的194例患者进行调查,并对相关资料进行整理。采用Logistic回归分析方法分析血常规中炎症指标与衰弱及衰弱前期的关联性。结果194例研究对象中,无衰弱患者(正常组)70例(36.08%),衰弱前期患者(衰弱前期组)45例(23.20%),衰弱患者(衰弱组)79例(40.72%)。无衰弱患者、衰弱前期患者和衰弱患者性别、年龄和病程比较,差异无统计学意义(P>0.05)。单因素Logistic回归分析显示,以衰弱前期组为参照组,中性粒细胞计数、C反应蛋白(CRP)与衰弱存在关联性;以正常组为参照组,白细胞计数、中性粒细胞计数、CRP与衰弱存在关联性。多因素Logistic回归分析结果表明,以正常组为参照组,CRP与衰弱存在关联性。结论炎症指标CRP与衰弱及衰弱前期均存在关联性,有望成为识别衰弱的炎症标志物。

Objective To explore the relationships of inflammatory markers with frailty and early stage of frailty.Methods A cross-sectional survey was used to investigate the patients hospitalized in the Department of Geriatric Medicine of Nanjing Drum Tower Hospital from March 2021 to November 2021,and the related data was summarized.Logistic regression analysis was used to analyze the association of inflammatory indicators of blood routine with frailty and its early stage.Results Of 194 subjects,70(36.08%)were non-frailty patients(normal group),45(23.20%)were pre-frailty patients(pre-frailty group),and 79(40.72%)were frailty patients(frailty group).There were no significant differences in gender,age and course of disease among patients without frailty,patients with pre-frailty and patients with frailty(P>0.05).Univariate Logistic regression analysis showed that taking the pre-frailty group as the reference group,the neutrophil count and C-reactive protein(CRP)were correlated with frailty;taking the normal group as the reference group,the white blood cell count,neutrophil count and C-reactive protein were correlated with frailty.Multivariate Logistic regression analysis showed that CRP was associated with frailty when the normal group was taken as the reference group.Conclusion The inflammatory index CRP is associated with frailty and its early stages,and is expected to be an inflammatory marker for frailty identification.