儿童炎症性肠病的精准治疗

Precision treatment in pediatric inflammatory bowel disease

我国儿童炎症性肠病(inflammatory bowel disease,IBD)的发病率不断上升,精准治疗可提高患儿的临床缓解及黏膜愈合率,提高儿童IBD的诊治水平。儿童IBD的精准治疗的发展主要基于对疾病发生发展认识的不断深入。生物制剂应用的不断优化可提高患儿的治疗效果,减轻经济负担。随着基因组学、转录组学、肠道微生态学及代谢组学等学科的发展及人工智能算法的协助,新的生物标志物不断被研究发现和应用。通过对儿童IBD精准化治疗的推动,IBD诊治策略将有新的改革和发展。

The incidence of pediatric inflammatory bowel disease(IBD)in China rose these years.Precision treatment can improve the treatment of IBD and increase the remission rate.The development of precision treatment is mainly based on the in-depth understanding of the pathogenesis of IBD.The continuous optimization of biologic applications can improve the treatment outcome of children and reduce the economic burden.New biomarkers are constantly discovered and applied with the development of genomics,transcriptomics,gut microbiome,metabolomics,and artificial intelligence algorithms.Precision treatment will innovate treatment strategies in the near future.