Egr1在肝癌中的研究进展

Research progress of Egr1 in liver cancer

肝癌是全球常见的恶性肿瘤,大多肝癌患者确诊时已处于中晚期。早期生长反应因子1(Egr1)是一种转录因子,在肝损伤期间被诱导,调控细胞增殖、肝损伤和修复过程中相关基因的表达,并且Egr1缺乏会延迟肝再生过程。最近的研究强调了Egr1在肝癌发生发展及治疗方面的双重作用。本文综述了Egr1在肝癌发生发展及治疗中可能的作用,并详细分析了Egr1参与的复杂信号途径,为临床疗效预测和发现新的治疗靶点提供参考。

Liver cancer is a common malignant tumor in the world.Most patients with liver cancer were in the middle and late stages when diagnosed.Early growth response factor 1(Egr1)is a transcription factor that is induced during liver injury and regulates the expression of genes involved in cell proliferation,involved in cell proliferation and the role of Egr1 in liver injury and repair,and the lack of Egr1 will delay the process of liver regeneration.Recent studies have emphasized the dual role of Egr1 in the occurrence,development and treatment of liver cancer,thus affecting the progress of liver cancer.This article reviews the possible role of Egr1 in the occurrence,development and treatment of liver cancer,and analyzes in details the complex signal pathways involved by Egr1,so as to provide reference for clinical efficacy prediction and discovery of new therapeutic targets.