肿瘤相关中性粒细胞与胰腺癌关系的研究进展

Research progress on the relationship between tumor-associated neutrophils and pancreatic cancer

胰腺癌是一种起病隐匿、预后不良的消化系统恶性肿瘤,具有早期诊断困难、进展期生存时间短等特点。胰腺癌的肿瘤微环境(Tumor microenvironment,TME)中常常伴有大量免疫细胞的浸润,而肿瘤相关中性粒细胞(Tumor-associated neutrophils,TANs)作为TME的重要组成部分,在肿瘤的进程中起着重要作用。相关研究表明,TANs在胰腺癌的TME中发挥多种作用。本文从TANs与胰腺癌的关系进行综述,为理解胰腺癌发生机制与提出新疗法提供思路。

Pancreatic cancer is a malignant tumor of digestive system with hidden onset and poor prognosis,which is characterized by difficult early diagnosis and short survival time in the advanced stage.The tumor microenvironment(TME)of pancreatic cancer is often accompanied by the infiltration of a large number of immune cells.As an important part of the TEM,tumor-associated neutrophils(TANs)play an important role in the process of tumor.Relevant studies have shown that TANs play multiple roles in the TME of pancreatic cancer.This article reviews the relationship between TANs and pancreatic cancer to provide ideas for understanding the pathogenesis of pancreatic cancer and proposing new therapies.