阻塞性睡眠呼吸暂停综合征与冠状动脉病变的关系探讨

The Relationship between Obstructive Sleep Apnea Syndrome and Coronary Artery Disease

目的:分析阻塞性睡眠呼吸暂停综合征与冠状动脉病变的关系。方法:选择2018年5月-2021年3月佳木斯市中心医院收治的50例接受冠状动脉造影检查患者作为研究对象,按照不同疾病类型将患者分成两组,其中阻塞性睡眠呼吸暂停综合征阳性合并冠心病组30例,阻塞性睡眠呼吸暂停综合征阴性合并冠心病组20例,对比两组患者的生命体征、冠状动脉病变程度及Gensini积分、颈动脉内膜中层厚度(IMT)及血清水平。结果:阴性组在接受冠状动脉造影确诊冠心病的患者为20例,阳性组接受冠状动脉造影确诊冠心病的患者为30例,发现阳性组患者发生冠心病的几率要高于阴性组。阳性组的冠状动脉病变程度要高于阴性组,差异无统计学意义(χ^(2)=1.7974、0.0613、1.2032、P>0.05);阳性组Gensini积分要高于阴性组,差异有统计学意义(t=4.5766,P<0.05);阳性组颈动脉IMT及血清水平Gensini积分要高于阴性组,差异有统计学意义(t=5.9830、6.8512、5.5741、5.4462,P<0.05)。结论:阻塞性睡眠呼吸暂停综合征与冠状动脉病变的关系比较密切,阻塞性睡眠呼吸暂停综合征的患者出现冠状动脉病变的几率要高于普通患者。

Objective:To analyze the relationship between obstructive sleep apnea syndrome and coronary artery disease.Methods:50 patients who received coronary angiography in the hospital from May 2018 to March 2021 were selected as the research subjects,and the patients were divided into two groups according to different disease types.Among them,there were 30 cases in the obstructive sleep apnea syndrome-positive group with coronary heart disease,and 20 cases in the obstructive sleep apnea syndrome-negative group with coronary heart disease.The vital signs,degree of coronary artery disease,Gensini score,carotid intima-media thickness(IMT)and serum levels were compared between the two groups.Results:There were 20 patients with coronary heart disease diagnosed by coronary angiography in the negative group,and 30 patients with coronary heart disease diagnosed by coronary angiography in the positive group.The probability of coronary heart disease in the positive group was higher than that in the negative group.The degree of coronary artery disease in the posirive group was higher than that of the negative group,the difference was not statistically significant(χ^(2)=1.7974,0.0613,1.2032,P>0.05)Gensini score of the positive group was higher than that of the negative group,and the differences were statistically significant(t=4.5766,P<0.05).The carotid IMT level and serum level the positive group were higher than that of the negative group,and the difference was statistically significant(t=5.9830,6.8512,5.5741,5.4462,P<0.05).Conclusion:Obstructive sleep apnea syndrome is closely related to coronary artery disease,and patients with obstructive sleep apnea syndrome have a higher risk of coronary artery disease than ordinary patients.