基于光声和LIBS双模态成像技术在生物医学中的发展现状及趋势

Development Status and Trend of Dual-modality Imaging Technology Based on Photoacoustics and LIBS in Biomedicine

光声成像和激光诱导击穿光谱技术(LIBS)是近些年在成像领域发展非常迅速的两种技术,在医学影像学方面有着巨大的潜力。当激光照射到组织时,组织表面会同时产生光声信号和等离子体,光声信号携带着生物组织内光吸收的特征信息,等离子体特征光谱也可以示踪组织内的元素信息。本文总结了两种技术的研究背景和成像原理,然后,通过对光声成像和LIBS成像模式进行分析,进一步展现了两种技术结合的可能性,并介绍了它们在病理切片成像和组织金属元素示踪等领域的应用。最后,我们对两种技术结合的双模态成像系统进行了深入的探讨和展望,以期其在医学诊断和图像领域发挥重要作用。

Photoacoustic imaging and laser induced breakdown spectroscopy are two technologies that have been developed very rapidly in the imaging field in recent years,and have great potential in medical imaging.When the laser irradiates the tissue,both the photoacoustic signals and plasma are generated on the surface of the tissue.The photoacoustic signal carries the characteristic information of light absorption in the tissue,and the characteristic spectrum of the plasma can also trace the element information in the tissue.This paper summarizes the research background and imaging principle of the two technologies,and further demonstrates the possibility of a combination of the two technologies by analyzing the photoacoustic imaging and LIBS imaging modes,and introduces their applications in the fields of pathological section imaging and tissue metal element tracing.Finally,we discuss and prospect the bimodal imaging system combining the two technologies,which is expected to play an important role in the field of medical diagnosis and imaging.