重组人脑利钠肽对难治性心衰治疗效果及NT-pro BNP、TnT、CRP水平的影响分析

Analysis of the Therapeutic Effect of Recombinant Human Brain Natri⁃uretic Peptide on Refractory Heart Failure and the Levels of NT-pro BNP,TnT and CRP

目的分析在治疗难治性心衰(RHF)过程中予以重组人脑利钠肽治疗的临床价值。方法便利选择2020年12月—2021年11月该院心内科及重症医学科收治的62例RHF患者为研究对象,以随机数表法将患者均分为两组,予以米力农治疗的31例纳入对照组,予以注射用重组人脑利钠肽及米力农序贯治疗的31例纳入观察组。对比两种治疗措施下患者治疗效果、生化指标水平、心功能指标水平及不良反应发生率。结果观察组治疗有效率(96.77%)显著高于对照组(74.19%),差异有统计学意义(χ^(2)=4.679,P<0.05)。治疗7 d后,观察组NT-pro BNP、TnT、CRP水平均优于对照组,差异有统计学意义(t=14.426、13.780、8.975,P<0.05)。观察组LVEF、SV、LVEDD水平均优于对照组,差异有统计学意义(t=5.295、4.263、4.628,P<0.05)。观察组不良反应发生率(6.46%)与对照组(9.69%)相比较差异无统计学意义(χ^(2)=0.000,P>0.05)。结论在RHF治疗中,予以重组人脑利钠肽治疗效果显著,使患者的生化指标及心功能均得到有效改善,安全性较高。

Objective To analyze the clinical value of recombinant human brain natriuretic peptide in the treatment of refractory heart failure(RHF).Methods A total of 62 RHF patients admitted to the Department of Cardiology and Intensive Care Medicine of the hospital from December 2020 to November 2021 were conveniently selected as the re‐search objects.The patients were divided into 2 groups by random number table method.31 patients who were treated with milrinone were included in the control group,and 31 patients who were treated sequentially with recom‐binant human brain natriuretic peptide for injection and milrinone were included in the observation group.The thera‐peutic effects,biochemical index levels,cardiac function index levels and the incidence of adverse reactions were compared under the two treatment measures.Results The treatment effective rate of the observation group 96.77%was significantly higher than the control group(74.19%),the difference was statistically significant(χ^(2)=4.679,P<0.05).After 7 d of treatment,the levels of NT-pro BNP,TnT and CRP in the observation group were better than those in the control group,the difference was statistically significant(t=14.426,13.780,8.975,P<0.05).The levels of LVEF,SV,and LVEDD in the observation group were better than those in the control group,the difference was statis‐tically significant(t=5.295,4.263,4.628,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the observation group(6.46%)and the control group(9.69%)(χ^(2)=0.000,P>0.05)Conclusion In the treatment of RHF,recombinant human brain natriuretic peptide has a significant effect,which can effectively improve the biochemical indexes and cardiac function of the patients,and the safety is high.