子宫动脉RI、血清NT-proBNP与妊娠异常结局的相关性分析

Correlation Analysis of Uterine Artery RI,Serum NT-probnp and Ab⁃normal Pregnancy Outcomes

目的分析子宫动脉阻力指数(RI)、血清氨基末端B型利钠肽前体(NT-proBNP)与妊娠异常结局的相关性。方法简单随机选取该院2020年1—12月住院分娩的100例妊娠期高血压(HDCP)孕妇,纳入HDCP组;另选取同时期该院住院分娩的100名健康孕妇,纳入对照组;对比两组孕妇子宫动脉RI与血清NT-proBNP检测结果、妊娠异常结局的发生率,分析子宫动脉RI、血清NT-proBNP与妊娠异常结局的相关性。结果HDCP组孕妇RI、血清NT-proBNP的检测值均高于对照组,差异有统计学意义(P<0.05);HDCP组孕妇的妊娠异常结局发生率高于对照组,差异有统计学意义(P<0.05);多因素Logistic回归分析结果显示,子宫动脉RI、血清NT-proBNP均是妊娠异常结局的影响因素。结论子宫动脉RI、血清NT-proBNP与妊娠异常结局之间存在明显的相关性,其联合检测可作为有效判断HDCP孕妇临床妊娠异常结局的生物学标志物。

Objective To analyze the correlation between uterine artery resistance index(RI),serum amino-terminal precursor B-type natriuretic peptide(NT-proBNP)and abnormal pregnancy outcomes.Methods A total of 100 preg‐nant women with hypertension during pregnancy(HDCP)who delivered in hospital from January to December 2020 in the hospital were simple randomly selected as the research objects and included in the HDCP group.Another 100 healthy pregnant women who delivered in the hospital during the same period in the hospital were selected as control subjects and included in the control group.The detection results of uterine artery RI and serum NT-probNP and the incidence of abnormal pregnancy outcome were compared between the two groups,and the correlation between uter‐ine artery RI and serum NT-probNP and abnormal pregnancy outcome was analyzed.Results The detection values of RI and serum NT-proBNP of pregnant women in HDCP group were higher than those in control group,the difference was statistically significant(P<0.05).The incidence of abnormal pregnancy outcomes of pregnant women in HDCP group was higher than that in control group,the difference was statistically significant(P<0.05).Multivariate Logistic regression analysis showed that uterine artery RI and serum NT-proBNP were the influencing factors of abnormal pregnancy outcomes.Conclusion There is a significant correlation between uterine artery RI,serum NT-proBNP and abnormal pregnancy outcomes,and their combined detection can be used as an effective biomarker for judging abnor‐mal clinical pregnancy outcomes of HDCP pregnant women.