补阳还五汤加减联合依达拉奉治疗气虚血瘀型脑梗死100例患者分析

Analysis of Buyang Huanwu Decoction Combined with Edaravone in the Treatment of 100 Patients with Cerebral Infarction of Qi Deficiency and Blood Stasis Type

目的研究100例气虚血瘀型脑梗死患者应用补阳还五汤加减联合依达拉奉治疗的效果。方法随机选取2019年3月—2021年3月该院收治的100例气虚血瘀型脑梗死患者为研究对象,并以等量电脑随机法均分为A组(n=50)和B组(n=50)。给予A组患者依达拉奉加基础治疗,B组患者展开依达拉奉联合补阳还五汤治疗,观察比较两组疗效。结果B组治疗总有效率96.00%高于A组的84.00%,差异有统计学意义(χ^(2)=4.000,P<0.05)。治疗后B组MMP-2及MMP-8指标水平均低于A组,B组FMA及Barthel指数评分均高于A组,治疗后7、14、21、24 d B组NIHSS评分均低于A组,差异有统计学意义(P<0.05)。结论气虚血瘀型脑梗死应用补阳还五汤与依达拉奉联合治疗,不仅具有显著临床疗效,还有助于降低血浆金属蛋白酶MMP-2及MMP-8水平,改善神经功能受损情况,同时还可以提升患者运动功能及生活自理能力,有利于提升患者生活质量,并促进其快速回归社会。

Objective To study the effect of Buyang Huanwu Decoction combined with edaravone in the treatment of 100 cases of cerebral infarction patients with Qi deficiency and blood stasis type.Methods A total of 100 patients with cerebral infarction of Qi deficiency and blood stasis type who were treated in the hospital from March 2019 to March 2021 were randomly selected as the study objects,and they were divided into group A(n=50)and group B(n=50)by equal computer randomization method.Patients in group A were given edaravone plus basic therapy,patients in group B were given edaravone combined with Buyang Huanwu Decoction,and the curative effects of the two groups were observed and compared.Results The total effective rate of group B was 96.00%higher than that of group A 84.00%,and the difference was statistically significant(χ^(2)=4.000,P<0.05).After treatment,the levels of MMP-2 and MMP-8 in group B were lower than those in group A,the FMA and Barthel index scores in group B were higher than those in group A,and the NIHSS scores of group B were lower than those of group A at 7 d,14 d,21 d and 24 d after treatment,and the difference was statistically significant(P<0.05).Conclusion The combined treatment of Buy‐ang Huanwu Decoction and edaravone in the treatment of cerebral infarction of Qi deficiency and blood stasis type not only has a significant clinical effect,but also helps to reduce the levels of plasma metalloproteinase MMP-2 and MMP-8,and improve the neurological impairment.At the same time,it can also improve the patient's motor function and self-care ability,which is beneficial to improve the patient's quality of life and promote their rapid return to society.