疤痕子宫剖宫产术中联合应用缩宫素与欣母沛对产后出血量的影响

Influence of Combined Use of Oxytocin and Xinmupei on Postpartum Hemorrhage During Cesarean Section of Scarred Uterus

目的探讨疤痕子宫剖宫产术中联合应用缩宫素与欣母沛对产后出血量的影响。方法选择2020年1月~2022年1月新余市人民医院收治的81例疤痕子宫行剖宫术患者为研究对象,按照随机数表法分为A组、B组、C组,各27例。A组采用缩宫素,B组在A组基础上联合欣母沛肌肉注射,C组在A组基础上联合欣母沛宫体注射。分析三组患者产后出血(产后2 h出血量、产后24 h出血量、产后出血率、输血率)情况;比较三组患者产前及产后2 h血常规相关指标[红细胞(RBC)、血红蛋白(HGB)]水平;比较三组患者术后48 h内药物不良反应发生情况差异。结果B、C组患者产后2 h出血量、产后24 h出血量、产后出血率、输血率均低于A组(P<0.05);B、C两组间产后2 h出血量、产后24 h出血量、产后出血率、输血率比较,差异无统计学意义(P>0.05)。产后2 h对比产前,三组患者RBC水平均升高(P<0.05),且B、C组明显高于同一时期A组(P<0.05),B、C两组产后2 h RBC水平比较,差异无统计学意义(P>0.05);产后2 h对比产前,三组HGB均降低(P<0.05),但B、C组HGB下降程度较A组差异有统计学意义(P<0.05),B、C两组HGB水平比较,差异无统计学意义(P>0.05)。术后48 h内,三组患者各项药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论疤痕子宫剖宫产术中应用缩宫素联合欣母沛,可有效减少患者术后出血量,改善患者RBC和HGB水平,两种给药方式均取得良好效果,且用药安全性良好,有利于预后。

Objective To investigate the eff ect of combined use of oxytocin and Xinmupei on postpartum hemorrhage during cesarean section of scarred uterus.Methods From January 2020 to January 2022,81 patients with scarred uterus undergoing cesarean section in Xinyu People's Hospital were selected as the research objects.According to the random number table method,they were divided into group A,group B and group C,27 cases in each group.Group A was given oxytocin,group B was given intramuscular injection of Xinmupei on the basis of group A,and group C was given intramuscular injection of Xinmupei on the basis of group A.The diff erences in postpartum hemorrhage(postpartum hemorrhage volume in 2 hours,postpartum hemorrhage volume in 24 hours,postpartum hemorrhage rate,blood transfusion rate)among the three groups were analyzed;the changes of blood routine related indicators[red blood cell(RBC)and hemoglobin(HGB)]before and 2 hours after delivery were compared among the three groups;the diff erences in the incidence of adverse drug reactions within 48 hours after surgery were compared among the three groups.Results The postpartum hemorrhage volume,24 h postpartum hemorrhage volume,postpartum hemorrhage rate and blood transfusion rate in groups B and C were lower than those in group A(P<0.05),there was no signifi cant diff erence in the amount of postpartum hemorrhage at 2 h,the amount of postpartum hemorrhage at 24 h,the rate of postpartum hemorrhage,and the rate of blood transfusion between the two groups(P>0.05).Signifi cantly increased(P<0.05),and groups B and C were signifi cantly higher than group A at the same period(P<0.05),and there was no signifi cant diff erence in RBC levels between groups B and C at 2 h postpartum(P>0.05).At 2 h postpartum compared with prepartum,HGB in the three groups was signifi cantly decreased(P<0.05),but there was signifi cant diff erence in the degree of HGB decline in groups B and C compared with group A(P<0.05),and there was no diff erence in HGB levels between groups B and C.Statistical signifi cance(P>0.05);within 48 hours after operation,there was no signifi cant diff erence in the incidence of adverse drug reactions among the three groups(P>0.05).Conclusion The application of oxytocin combined with Xinmupei in cesarean section of scarred uterus can eff ectively reduce the postoperative bleeding volume and improve the levels of RBC and HGB in patients.It is benefi cial to its prognosis recovery.