人乳头瘤病毒感染与泌尿生殖道支原体感染及其耐药率相关性分析

Correlation analysis between human papillomavirus infection and urogenital mycoplasma infection and drug resistance rate

目的探讨人乳头瘤病毒(HPV)感染与泌尿生殖道支原体感染及耐药的相关性。方法对2018年9月至2020年3月在该院妇科就诊检测HPV和泌尿生殖道支原体的204例女性患者病历资料进行回顾性分析。结果HPV阳性患者泌尿生殖道支原体阳性率[56.0%(47/84)]高于HPV阴性患者[34.2%(41/120)],差异有统计学意义(P<0.05)。对支原体各感染类型对比分析发现,HPV阳性患者解脲脲原体阳性率[41.7%(35/84)]高于HPV阴性患者[26.7%(32/120)],差异有统计学意义(P<0.05);而人型支原体、混合感染阳性率比较[1.2%(1/84)vs.3.3%(4/120)、9.5%(8/84)vs.6.7%(8/120)],差异均无统计学意义(P>0.05)。按年龄分组比较发现,≤30岁年龄组中HPV阳性患者的泌尿生殖道支原体阳性率[57.7%(30/52)]明显高于HPV阴性患者[32.3%(21/65)],差异有统计学意义(P<0.05);而>30岁年龄组中支原体阳性率比较[53.1%(17/32)vs.36.4%(20/55)],差异无统计学意义(P>0.05)。对解脲脲原体药敏结果分析发现,HPV阴性和HPV阳性患者药敏结果表现出较强的一致性,各研究药物的耐药率对比,差异均无统计学意义(P>0.05),两者敏感率最高的是交沙霉素。结论泌尿生殖道支原体感染与HPV感染具有相关性,解脲脲原体的耐药率与HPV感染无明显相关性。

Objective To investigate the correlation between human papillomavirus(HPV)infection and urogenital mycoplasma infection and drug resistance.Methods A retrospective analysis was performed for the case data of 204 female patients who were tested for HPV and urogenital mycoplasma tract in the gynecology department of this hospital from September 2018 to March 2020.Results The positive rate of urogenital mycoplasma in HPV-positive patients[56.0%(47/84)]was significantly higher than that in HPVnegative patients[34.2%(41/120)],with a statistically significant difference(P<0.05).Comparative analysis of the mycoplasma infection types showed that,the positive rate of ureaplasma urealyticum in HPV-positive patients[41.7%(35/84)]was higher than that in HPV-negative patients[26.7%(32/120)],with statistically significant differences(P<0.05),while the comparison of positive rates for mycoplasma hominis and mixed infection[1.2%(1/84)vs.3.3%(4/120),9.5%(8/84)vs.6.7%(8/120)]showed that there were no significant differences(P>0.05).Comparison by age group showed that the positive rate of mycoplasma in urogenital tract of HPV-positive patients in the less than or equal to 30 years old age group[57.7%(30/52)]was significantly higher than that of HPV-negative patients[32.3%(21/65)],with a statistically significant difference(P<0.05);compared to the mycoplasma positivity in the greater than 30 years old age group[53.1%(17/32)vs.36.4%(20/55)],the difference was not statistically significant(P>0.05).Analysis of ureaplasma urealyticum drug sensitivity results showed that HPV-negative and HPV-positive patients showed a strong consistency in the drug-sensitivity results,and there was no significant difference in drug resistance rates among the drugs studies(P>0.05).And the highest sensitivity rate of the two was josamycin.Conclusion Urogenital mycoplasma infection is related to HPV infection,and the rate of drug resistance of ureaplasma urealyticum is not related to HPV infection.