VEGF-VEGFR2信号通路在银屑病中作用的研究进展

Role of VEGF-VEGFR2 signaling pathway in psoriasis

VEGF-VEGFR2信号通路在银屑病病程中发挥重要作用。血管内皮因子(VEGF)与VEGFR2结合可以在多个酪氨酸位点诱导受体二聚化和自身磷酸化,同时促进下游信号ERK1/2通路的激活。磷酸化的ERK1/2在银屑病皮损处角质形成细胞中高表达,而VEGFR2被VEGF激活后又可诱导ERK1/2磷酸化,促进角蛋白K6、K16和K17的表达,同时激活的ERK1/2又将促进炎症反应的发生以及血管增生。因此通过阻断VEGF介导的VEGF-VEGFR2信号转导通路,可影响VEGF-VEGFR2信号转导通路下游基因的表达。VEGF-VEGFR2信号通路上的关键分子VEGF和VEGFR2可以作为银屑病治疗的潜在靶点。VEGF抑制剂可以通过抑制VEGF或VEGFR2来阻断VEGF-VEGFR2信号通路,从而发挥对银屑病的治疗作用。本文对近年来VEGF-VEGFR2通路参与银屑病机制的研究进行综述。

VEGF-VEGFR2 signaling pathway plays an important role in the course of psoriasis.Binding of VEGF to VEGFR2 induces receptor dimerization and autophosphorylation at multiple tyrosine sites,promoting the activation of the downstream ERK1/2 signaling pathway.Phosphorylated ERK1/2 is highly expressed in keratinocytes in psoriatic lesions,while VEGFR2 activation induces ERK1/2 phosphorylation and upregulates the expression of keratin K6,K16,and K17.At the same time,the activation of ERK1/2 can enhance inflammatory response and vascular proliferation.Therefore,blockade of VEGF-mediated vegF-VEGFR2 signaling pathway can regulate the expression of downstream genes in VEGF-VEGFR2 signaling pathway.VEGF and VEGFR2,the key molecules in VEGF-VEGFR2 signaling pathway,may serve as potential therapeutic targets for psoriasis.VEGF inhibitors can block vegF-VEGFR2 signaling pathway by inhibiting VEGF or VEGFR2,playing a therapeutic role in psoriasis.In this review,we review the recent advances in the involvement of VEGF-VEGFR2 pathway in psoriasis.