辛伐他汀与瑞舒伐他汀对冠心病患者血脂水平的影响

Effect of simvastatin and rosuvastatin on blood lipid levels in patients with coronary heart disease

目的分析辛伐他汀与瑞舒伐他汀对冠心病(CHD)患者血脂水平的影响。方法选取罗定市中医院收治的CHD患者120例为研究对象,入院时间2020年6月至2021年6月,采用随机数表法分为A组(n=60)和B组(n=60)。B组患者采用辛伐他汀片治疗,A组患者则运用瑞舒伐他汀片治疗。比较两组治疗后血脂水平及临床指标等。结果治疗前,两组血脂指标比较,差异无统计学意义(P>0.05);治疗后,A组总胆固醇(4.38±0.35)、三酰甘油(1.03±1.87)、低密度脂蛋白胆固醇(2.03±0.47)水平均低于B组的(5.08±0.23)、(1.94±1.42)、(2.94±0.49),高密度脂蛋白胆固醇(1.63±0.27)水平高于B组(1.44±0.19),差异有统计学意义(P<0.05)。A组心绞痛持续时间(1.38±0.30)和频率(1.03±0.87)均低于B组的(3.08±1.19)、(3.94±0.53),差异有统计学意义(P<0.05);A组治疗总有效率(98.33%)高于B组(80.00%),A组(8.33%)不良事件发生率低于B组(21.67%),差异有统计学意义(P<0.05)。结论瑞舒伐他汀较辛伐他汀对CHD患者治疗效果显著,能有效改善患者临床症状与血脂指标,且不良反应率低,预后效果良好,具有更高的安全性,可广泛应用于临床。

Objective To analyze the effect of simvastatin and rosuvastatin on blood lipid levels in patients with coronary heart disease(CHD).Methods A total of 120 CHD patients admitted to Luoding Hospital of Traditional Chinese Medicine from June 2020 to June 2021 were included in the study and randomly divided into group A(n=60)and group B(n=60)according to the random number table method.Patients in group B were treated with simvastatin tablets,while patients in group A were treated with rosuvastatin tablets.The changes of blood lipid levels and clinical indicators after treatment were compared between the two groups.Results Before treatment,there were no significant differences in blood lipid levels and clinical indexes between the two groups(P>0.05).After treatment,the levels of TC(4.38±0.35),TG(1.03±1.87)and LDL-C(2.03±0.47)in group A were lower than those in group B(5.08±0.23;1.94±1.42;2.94±0.49),and the level of HDL-C(1.63±0.27)in group A was higher than that in group B(1.44±0.19),and the differences were statistically significant(P<0.05).The duration(1.38±0.30)and frequency(1.03±0.87)of angina pectoris in group A were lower than those in group B(3.08±1.19,3.94±0.53),and the differences were statistically significant(P<0.05).The therapeutic effect in group A(98.33%)was higher than that in group B(80.00%),and the adverse reaction rate in group A(8.33%)was lower than that in group B(21.67%),and the differences were statistically significant(P<0.05).Conclusion Compared with simvastatin,rosuvastatin has more obvious therapeutic effect on CHD patients,which can effectively improve the clinical symptoms and blood lipid indexes of patients,with low adverse reaction rate,good prognosis effect,and higher safety.Therefore,it can be widely used in clinical practice.