有氧运动在膝骨关节炎中的研究进展

Research progress of aerobic exercise for knee osteoarthritis

膝骨关节炎(KOA)是一种常见慢性疾病,可导致患者生活质量下降,甚至残疾,给个人、家庭及社会均带来严重影响,然而治疗药物及效果十分有限。有氧运动被认为是治疗KOA的有效手段,但对运动处方的研究缺乏明确分级,运动的动作、强度、时间、频率等因素也参差不齐,另外各种细胞因子作用机制研究不明确。因此不同的运动类型、运动量与KOA治疗效果间的关联性及稳定的运动处方的相关细胞因子等还需进一步研究。本文就目前国内外关于有氧运动处方、细胞因子及信号通路进行综述,为后期深入研究提供依据。

Knee osteoarthritis(KOA)is a common chronic disease,which can lead to the decline of patients’quality of life and even disability,and exert an adverse impact on individuals,families and the society.However,the therapeutic drugs and effects are very limited.Aerobic exercise is considered to be an effective means to treat KOA,but the exercise prescriptions under study are lack of clear classification,and the action,intensity,duration,frequency and other factors of exercise are also varying.In addition,the action mechanism of various cytokines under study is not clear.Therefore,the relationship between different types of exercise or amount of exercise and the therapeutic effect of KOA,as well as the related cytokines of stable exercise prescription,need to be further studied.This paper reviews the current prescriptions,cytokines and signaling pathways of aerobic exercise at home and abroad,so as to provide basis for further research in the later stage.