用于引导骨再生的个性化钛网的生物力学研究

Biomechanical characterization of individualized Ti-mesh for alveolar bone defects

目的探讨厚度、孔径大小对个性化钛网力学性能的影响及钛网引导骨再生的效果。方法建立不同厚度及孔径个性化钛网的有限元模型并输出应力,以筛选理想厚度及孔径;随后将钛网植入比格犬颌骨缺损内,通过Micro-CT及组织切片观察钛网引导成骨效果。结果钛网力学性能随厚度增加而增强,随孔径增大而变差。0.4-3、0.4-4两种钛网力学性能更适合临床。动物实验显示钛网联合引导骨再生可以修复牙槽骨缺损,在骨缺损区可见大量新生骨形成。结论0.4-3、0.4-4两种钛网具有形态佳、力学性能优、简单方便、精度高等优点,个性化钛网用于引导骨再生安全可靠,且术后暴露率低,具备临床可行性。

Objective To investigate the influence of thickness and pore size on the mechanical properties of individualized titanium mesh and the effect of the individualized titanium mesh for guided bone regeneration.Methods The finite element models of individualized titanium mesh with different thickness and pore size were established.Individualized titanium mesh was implanted into the jaw defect of Beagle dogs.Micro-CT and histology analysis were used to evaluate the effect of guided bone regeneration of the individualized titanium mesh.Results The mechanical properties of the titanium mesh was enhanced with the thickness increasing,while the mechanical properties of the mesh was enhanced with the mesh diameter reducing.The 0.4-3 and 0.4-4 titanium meshes were more suitable for clinical use from the perspective of mechanical properties.Animal study showed that the individualized titanium mesh combined with guided bone regeneration could effectively repair the alveolar bone defects.Conclusions The individualized titanium mesh(0.4-3,0.4-4)with satisfied shape and mechanical properties could match the bone defects.The individualized titanium mesh was clinically feasible.