血清NF-κB、CRP、IL-6及TNF-α水平与精神分裂症合并2型糖尿病的相关性

Correlation of the levels of serum NF-κB,CRP,IL-6,and TNF-αwith schizophrenia complicated with type 2 diabetes mellitus

目的 分析血清核转录因子-κB(NF-κB)、C反应蛋白(CRP)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平测定对精神分裂症(SP)患者合并2型糖尿病(T2DM)的临床意义。方法 98例SP患者、根据是否合并T2DM分为单纯SP组与SPDM组,采用酶联免疫吸附(ELISA)法检测2组患者血清核转录因子-κB(NF-κB)、C反应蛋白(CRP)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α水平),采用Pearson相关性分析单纯SP组、SPDM组及所有SP患者血清NF-κB、CRP、IL-6及TNF-α表达水平与空腹血糖(FPG)的相关性,通过绘制受试者工作特征曲线(ROC)下面积(AUC)评估各指标对SP患者合并T2DM的诊断效能。结果 SP患者中合并T2DM发病率为22.45%(22例),SPDM组年龄、体质量指数(BMI)、FPG水平及血清NF-κB、CRP、IL-6及TNF-α水平均高于单纯SP组,差异有统计学意义(P <0.05);所有SP患者血清CRP、IL-6、TNF-α水平与FPG水平呈正相关(r=0.469、0.350、0.443,P <0.001),ROC分析结果显示,血清NF-κB、CRP、IL-6及TNF-α水平联合诊断SP合并T2DM的AUC为0.830、灵敏度为86.4%、特异度为89.5%,高于任一指标单独检测。结论 SP合并T2DM患者血清NF-κB、CRP、IL-6及TNF-α水平较单纯SP患者升高,4项指标联合检测对诊断SP合并T2DM具有较高的价值。

Objective To analyze clinical significance of the levels of serum nuclear transcription factors-κB(NF-κB),C reactive protein(CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)in determining patients with schizophrenia(SP)complicated with type 2 diabetes mellitus(T2DM).Methods Ninety-eight patients with SP were divided into SP alone and SPDM groups according to whether they had T2DM.The levels of serum NF-κB,CRP,IL-6,and TNF-αin serum were detected by enzyme linked immunosorbent assay(ELISA).Pearson correlation was performed to analyze the correlation of the levels of NF-κB,CRP,IL-6,and TNF-αwith fasting blood glucose(FBG)in SP alone group,SPDM group and all patients with SP.The diagnostic efficacy of each index for SP patients complicated with T2DM was evaluated by the area under the receiver operating characteristic(ROC)curve(AUC).Results The incidence rate of T2DM in SP patients was 22.45%(n=22).Age,body mass index(BMI),the levels of FBG,serum NF-κB,CRP,IL-6,and TNF-αin SPDM group were significantly higher than those of SP alone group(P<0.05).The levels of serum CRP,IL-6,TNF-αin all SP patients were positively correlated with the FBG level(r=0.469,0.350,0.443;P<0.001).ROC analysis showed that the AUC,sensitivity,and specificity of the combination of serum NF-κB,CRP,IL-6,and TNF-αin diagnosing SP complicated with T2DM were 0.830,86.4%,and 89.5%,respectively,which were higher than those of any single indicator.Conclusion The levels of NF-κB,CRP,IL-6,and TNF-αin the patients with SP complicated with T2DM are higher than those in the patients with SP alone.Their combination is of high value in diagnosing SP complicated with T2DM.