培哚普利联合氢氯噻嗪治疗原发性高血压合并慢性心力衰竭的临床效果及对患者心功能、炎性因子水平的影响

Clinical effect of perindopril combined with hydrochlorothiazide in the treatment of essential hypertension complicated with chronic heart failure and its influences on cardiac function and inflammatory factors levels of patients

目的分析培哚普利联合氢氯噻嗪治疗原发性高血压合并慢性心力衰竭的临床效果。方法选取我院2019年9月至2020年6月收治的64例原发性高血压合并慢性心力衰竭患者作为研究对象,按照随机双盲法将其分为对照组与研究组,每组32例。对照组给予氢氯噻嗪治疗,研究组在对照组基础上加用培哚普利治疗。比较两组的治疗效果。结果研究组的治疗总有效率显著高于对照组(P<0.05)。治疗后,两组的舒张压、收缩压、心率均降低,且研究组显著低于对照组(P<0.05)。治疗后,两组的左心室射血分数(LVEF)均升高,左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)及B型脑尿钠肽(BNP)水平均降低,且研究组显著优于对照组(P<0.05)。治疗后,两组的白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)水平均降低,且研究组显著低于对照组(P<0.05)。治疗后,两组的一氧化氮(NO)水平均升高,内皮素-1(ET-1)水平均降低,且研究组显著优于对照组(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论培哚普利联合氢氯噻嗪治疗原发性高血压合并慢性心力衰竭的效果确切,可有效抑制血管壁炎症反应,改善患者心功能,且安全性高。

Objective To analyze the clinical effect of perindopril combined with hydrochlorothiazide in the treatment of essential hypertension complicated with chronic heart failure.Methods A total of 64 patients with essential hypertension complicated with chronic heart failure admitted in our hospital from September 2019 to June 2020 were selected as the research objects and divided into control group and study group according to the random double-blind method,with 32cases in each group.The control group was treated with hydrochlorothiazide,and the study group was treated with perindopril on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the study group was significantly higher than that in the control group(P<0.05).After treatment,the diastolic blood pressure,systolic blood pressure and heart rate of the two groups decreased,and those in the study group were significantly lower than the control group(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)in two groups increased,while the left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD)and B-type natriuretic peptide(BNP)level decreased,and those in the study group were significantly better than the control group(P<0.05).After treatment,the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and hypersensitive C-reactive protein(hs-CRP)in the two groups decreased,and those in the study group were significantly lower than the control group(P<0.05).After treatment,the level of nitric oxide(NO)in the two groups increased,and the level of endothelin-1(ET-1)decreased,and those in the study group were significantly better than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Perindopril combined with hydrochlorothiazide in the treatment of essential hypertension complicated with chronic heart failure has definite effect,which can effectively inhibit the inflammatory reaction of vascular wall,and improve the cardiac function of patients,with high safety.