摘要
冠心病(CHD)是一种以慢性炎症反应和斑块堆积为特征的心血管疾病,最终导致心肌细胞的缺氧和坏死。近年来研究发现,Toll 4样受体(TLR4)与冠状动脉病变进展密切,本文就TLR4与冠状动脉病变可能机制作一综述,以期为延缓冠状动脉病变及治疗提供新思路。
Coronary heart disease(CHD)is a cardiovascular disease characterized by chronic inflammatory response and plaque accumulation,which eventually leads to hypoxia and necrosis of the cardiac myocytes.This paper reviews the possible mechanisms of the toll-like receptor 4(TLR4)and coronary artery lesions in order to provide new ideas for delaying coronary artery lesions and their treatment.
作者
雷运臻
袁正强
李波涛
梁鹏
LEI Yun-zhen;YUAN Zheng-qiang;LI Bo-Tao;LIANG Peng(Dardiovascular medicine department,Third Affiliated Hospital of Zunyi Medical University,Zunyi 563099,China)
出处
《中国心血管病研究》
CAS
2022年第11期1014-1019,共6页
Chinese Journal of Cardiovascular Research
基金
贵州省卫生健康委科学技术基金项目(GZWKJ 2022-313)。
关键词
TOLL样受体4
冠心病
冠状动脉粥样硬化
冠状动脉病变
Toll-like receptor 4
Coronary heart disease
Acute myocardial infarction
Coronary atherosclerosis
