经导管肺动脉瓣置换术的临床应用研究进展

Progress in transcatheter pulmonary valve replacement

先天性心脏病(CHD)是最常见的先天性畸形,常常伴随右心室流出道(RVOT)异常。在首次外科手术矫正RVOT异常后,多数患者并发肺动脉瓣异常,需要多次进行肺动脉瓣置换,外科手术的风险极高。经导管肺动脉瓣置换装置(TPVR)给CHD患者带来希望,并成为肺动脉瓣异常有效的治疗方案,同时也面临诸多挑战。本文围绕TPVR治疗方式的特点、临床应用结果、并发症等进行概述。

Congenital heart disease(CHD)is the most common of congenital defects,which often accompanies by abnormalities of the right ventricular outflow tract(RVOT).After the initial surgical correction of the RVOT abnormality,most patients suffer pulmonary valve anomalies and require multiple surgical pulmonary valve replacements with high surgical mortality.Transcatheter pulmonary valve replacement(TPVR)has emerged as a promising alternative to the surgery,and TPVR faces many challenges at the same time.This review summarizes the characteristics,clinical trials results and complications of TPVR.