基于多酚质量传递规律视角下的余甘子质量标准研究思路

Research Ideas on Quality Standards of Phyllanthus emblica from the Perspective of Polyphenol Mass Transfer Law

余甘子是我国西南地区特色药食同源品种。目前,余甘子质控标准国际上可参考的主要有《英国药典》《印度药典》《香港中药材标准》和《中华人民共和国药典》,主要以没食子酸和鞣花酸为评价指标。然而,作为余甘子重要药效物质基础的多酚(鞣质)在贮藏和加工过程中具有特殊的转化与传递规律。现有质量评价方法仅以没食子酸和鞣花酸作为评价指标,难以合理有效评价余甘子的质量。为此,本文基于余甘子多酚成分转化传递规律,结合余甘子应用现状及现有余甘子药典标准,对余甘子质量标准研究思路与制定进行探讨。

Phyllanthus emblica is a characteristic medicinal food species in southwest China.At present,the main international reference standards for P.emblica quality control are British Pharmacopoeia,Indian Pharmacopoeia,Hong Kong Standards for Chinese Medicinal Materials,and Pharmacopoeia of the People's Republic of China,mainly based on gallic acid and ellagic acid as evaluation indicators.However,polyphenols(ellagitannins),which are the important medicinal substances in P.emblica,have special transformation and transmission rules during storage and processing.The existing quality evaluation methods only use gallic acid and ellagic acid as evaluation indexes,which are difficult to evaluate the quality of P.emblica reasonably and effectively.Therefore,this paper discussed the research ideas and development of P.emblica quality standards based on the mass transfer laws of P.emblica polyphenol components,combined with the current situation of P.emblica applications and existing standards of P.emblica in the pharmacopeia.