羟考酮联合普瑞巴林治疗晚期骨癌痛患者的疗效及对生存期的影响

Effect of oxycodone combined with pregabalin in the treatment of patients with advanced bone cancer pain and its impact on survival

目的观察羟考酮联合普瑞巴林治疗晚期骨癌痛患者的疗效及对生存期的影响。方法将50例晚期骨癌痛患者按照治疗方案的不同分为羟考酮组(OXY组)27例和羟考酮联合普瑞巴林组(OXY+PRE组)23例,OXY组口服羟考酮,OXY+PRE组口服羟考酮和普瑞巴林,采用数字分级评分法(NRS)比较两组患者治疗后的疼痛缓解率,采用生活质量评分(QOL)评价两组患者生活质量,每周电话随访统计两组患者中位生存时间及生存情况。结果OXY+PRE组患者疼痛缓解有效率高于OXY组,差异有统计学意义(P﹤0.05)。治疗后,两组患者QOL评分均较治疗前明显上升,且OXY+PRE组患者QOL评分明显高于OXY组患者,差异均有统计学意义(P﹤0.01)。两组患者中位生存时间及6、12、18个月生存率比较,差异均无统计学意义(P﹥0.05)。结论羟考酮联合普瑞巴林治疗较羟考酮单药治疗能显著减轻晚期骨癌痛患者疼痛,并可显著提高骨癌痛患者的生活质量,但是患者的中位生存期及远期生存率未见明显改善。

Objective To observe the effect of oxycodone combined with pregabalin in the treatment of patients with advanced bone cancer pain and its impact on survival.Method A total of 50 patients with advanced bone cancer pain were divided into oxycodone group(OXY group)with 27 cases and oxycodone plus pregabalin group(OXY+PRE group)with 23 cases according to different treatment regimens.Among them,the OXY group was orally administered oxycodone,and the OXY+PRE group was orally administered oxycodone and pregabalin.The numerical rating scale(NRS)was used to compare the pain relief rate after the treatment in the two groups.The quality of life(QOL)was used to evaluate the quality of life of the two groups of patients.The median survival time and survival status of the patients in the two groups were calculated weekly and by telephone follow-up.Result The objective rate of pain relief in the OXY+PRE group was higher than that in the OXY group,and the difference was statistically significant(P<0.05).After the treatment,the QOL scores of the two groups were significantly increased compared with themselves before the treatment,and the score of the OXY+PRE group was significantly higher than that of the OXY group,and the differences were statistically significant(P<0.01).There were no significant difference in the median survival time and 6-,12-,and 18-month survival between the two groups(P>0.05).Conclusion Compared with oxycodone monotherapy for patients with bone cancer pain,oxycodone combined with pregabalin can significantly reduce pain in patients with advanced bone cancer pain,and significantly improve patients’quality of life.However,the median survival and long-term survival of patients were not significantly improved.