氯胺酮治疗抑郁症的过去、现在及未来

Ketamine for depression treatment:past,present,and future

抑郁症由于其较高的发病率和极大的危害性,已成为严重的全球公共卫生问题,引起了全社会的关注。氯胺酮作为临床上常用的静脉麻醉镇痛药,近年来发现其在抗抑郁方面具有独特的优势,随着研究的深入,氯胺酮的对映异构体(S)-氯胺酮和(R)-氯胺酮进入了抗抑郁治疗的研究领域。在本文中,我们回顾了氯胺酮、(S)-氯胺酮和(R)-氯胺酮的抗抑郁作用及机制的研究进展,并对氯胺酮的代谢产物的抗抑郁作用进行了简单的介绍,以期加深读者们对氯胺酮抗抑郁研究领域的了解。

Depression has become a serious global public health problem due to its high incidence and great harm,and has aroused the attention of the society.Ketamine,a commonly used intravenous anesthetic and analgesic in clinical practice,has been found to have unique advantages in antidepressant therapy in recent years.With the development of research,the enantiomeric isomers of ketamine,(S)-ketamine and(R)-ketamine have entered the research field of antidepressant therapy.In this paper,we reviewed the progress of research on the antidepressant effects and mechanisms of ketamine,(S)-ketamine and(R)-ketamine,and provide a brief overview of the antidepressant effects of metabolites of ketamine,thereby deepening the understanding of the readers in the field of antidepressant effects of ketamine.