动脉硬化性脑梗死患者血清NOS3、GDNF水平及其临床意义

Serum NOS3 and GDNF levels in patients with arteriosclerotic cerebral infarction and their clinical significance

目的探究动脉硬化性脑梗死患者血清内皮型一氧化氮合酶(NOS3)、胶质细胞源性神经营养因子(GDNF)表达差异以及其在患者预后中的作用。方法选取2021年1月-2022年1月期间本院收治的动脉硬化性脑梗死患者126例及同期体检健康者130例,患者根据梗死体积、功能障碍、预后分组,比较不同组间血清NOS3、GDNF水平;使用ROC曲线分析NOS3、GDNF对患者预后不良的预测价值。结果动脉硬化性脑梗死患者糖尿病史、高血压病史比例升高,血清NOS3、GDNF水平降低(P<0.05);不同梗死体积患者NOS3、GDNF水平差异无统计学意义(P>0.05);轻度功能障碍组、中度功能障碍组、重度功能障碍组患者NOS3、GDNF水平依次降低(P<0.05);NOS3、GDNF水平预测患者预后不良AUC分别为0.858、0.779。结论动脉硬化性脑梗死患者血清NOS3、GDNF水平均降低,其水平与患者的神经功能缺损程度以及预后相关,有望成为评估患者预后情况的生物学指标。

Objective To investigate the expression differences of serum endothelial nitric oxide synthase(NOS3)and glial cell-derived neurotrophic factor(GDNF)in patients with arteriosclerotic cerebral infarction and their role in the prognosis of patients.Methods A total of 126 patients with atherosclerotic cerebral infarction admitted to our hospital from January 2021 to January 2022 and 130 healthy people in the same period were selected.Patients were divided into groups according to infarct volume,dysfunction and prognosis,and serum NOS3 and GDNF levels were compared between different groups.ROC curve was used to analyze the predictive value of NOS3 and GDNF for poor prognosis.Results The proportion of diabetes and hypertension in patients with atherosclerotic cerebral infarction increased,and the serum levels of NOS3 and GDNF decreased(P<0.05).There was no significant difference in the levels of NOS3 and GDNF among patients with different infarct volumes(P>0.05).The levels of NOS3 and GDNF in mild dysfunction group,moderate dysfunction group and severe dysfunction group decreased successively(P<0.05).The AUC of NOS3 and GDNF levels in predicting poor prognosis were 0.858 and 0.779,respectively.Conclusion The serum levels of NOS3 and GDNF in patients with atherosclerotic cerebral infarction are decreased,and their levels are related to the degree of neurological impairment and prognosis of patients,which is expected to be a biological indicator to evaluate the prognosis of patients.