布地奈德联合甲泼尼龙治疗支气管哮喘急性发作的临床疗效分析

Clinical Efficacy Analysis of Budesonide Combined with Methylprednisolone in Treatment of Acute Attack of Bronchial Asthma

目的:分析布地奈德联合甲泼尼龙治疗支气管哮喘急性发作的临床疗效。方法:选取2019年7月-2021年7月佛山市顺德区伦教医院收治的支气管哮喘急性发作患者40例为观察对象,按照随机数表法分为对照组与观察组,各20例。对照组给予布地奈德治疗,观察组在对照组基础上联合甲泼尼龙治疗。比较两组患者临床疗效、肺功能、生活质量及不良反应发生率。结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,观察组患者第1秒用力呼气的容积、第1秒用力呼气的容积占预计值的百分比、最大呼气流量水平高于对照组,差异有统计学意义(P<0.05);治疗后,观察组生理功能、躯体疼痛与社会功能评分高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:布地奈德雾化吸入与甲泼尼龙静滴治疗支气管哮喘急性发作,疗效显著,可有效提升患者生活质量,用药方案安全可靠。

Objective:To analyze clinical efficacy of budesonide combined with methylprednisolone in the treatment of acute attack of bronchial asthma.Methods:Forty patients with acute attack of bronchial asthma in Lunjiao Hospital in Shunde District of Foshan City from July 2019 to July 2021 were selected as the observation subjects,and they were divided into control group and observation group according to random digital number table method,with 20 cases in each group.The control group was treated with budesonide,while the observation group was treated with methylprednisolone on the basis of the control group.The clinical efficacy,pulmonary function,quality of life and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the forced expiratory volume in first second,the percentage of forced expiratory volume in first second to the expected volume,and the maximum expiratory flow level of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05);After treatment,the physiological function,somatic pain and social function scores of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05);The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Budesonide atomization inhalation and methylprednisolone intravenous drip in the treatment of acute attack of bronchial asthma have significant efficacy,it can effectively improve the quality of life of patients,and the drug regimen is safe and reliable.