MAP4K1影响T细胞在肿瘤微环境中的功能研究进展

Research progress in MAP4K1 affecting the function of T cells in tumor micro-environment

目前,恶性肿瘤的发病率和病死率逐年上升,而就现有的治疗手段而言,能够治愈的寥寥无几,在机体抗肿瘤机制中,T细胞介导的细胞免疫至关重要。丝裂原活化蛋白激酶1(mitogen-activated protein kinase 1,MAP4K1)作为一种免疫抑制调节激酶,负调节T细胞表面特异的抗原受体信号,参与T细胞在肿瘤微环境中的活化、增殖、细胞迁移和效应等重要免疫过程,有望成为恶性肿瘤免疫治疗的新靶点。本文总结了以往关于MAP4K1影响T细胞在肿瘤微环境中的各方面功能的研究,有助于阐明MAP4K1在肿瘤免疫治疗中的重要意义,并为研发以MAP4K1为靶点的药物提供新的思路。

The incidence and mortality of malignant tumors is increasing every year,and very few can be cured with current therapies.As an immunosuppressive regulatory kinase,mitogen-activated protein kinase 1 (MAP4K1) negatively regulates the specific antigen receptors on the surface of T cells (TCR) signals.MAP4K1 is involved in the activation,proliferation,cell migration and effect of T cells in tumor micro-environment,and is expected to be a new target for the immunotherapy of malignant tumors.This paper summarized previous studies on various aspects of MAP4K1 affecting the function of T cells in tumor micro-environment,which helps to clarify the importance of MAP4K1 in tumor immunotherapy,and provides a new idea for the development of drugs targeting MAP4K1.