阿尔茨海默病的Aβ级联机制研究进展

Research Progress of AβCascade in Alzheimer’s Disease

阿尔茨海默病(Alzheimer’s disease,AD)是一种慢性进展性神经系统退行性疾病,β-淀粉样蛋白(amyloidβ-protein,Aβ)沉积所形成的老年斑是其主要病理特征之一,而Aβ级联学说也成为目前较为公认、热点研究的AD发病机制之一。本文将从Aβ引发神经元凋亡、突触功能障碍、神经炎症及tau蛋白过磷酸化等方面,对AD的Aβ级联机制研究进展予以综述,为进一步集成化、整体性研究AD的Aβ级联机制提供支持。

Alzheimer’s disease(AD)is a chronic progressive neurodegenerative disease,and amyloidβ-protein(Aβ)deposit derived senile plaques(SPs)in the brain are one of the main pathological features.The Aβcascade theory has also become one of the most recognized hot topics in the study of AD pathogenesis.This paper reviews the research progress of Aβcascade in AD,including Aβ-induced neuronal apoptosis,synaptic dysfunction,neuroinflammation and tau protein hyperphosphorylation,etc,and may provide support for further integrated and holistic research on Aβcascade mechanism of AD.