肝细胞癌肿瘤免疫微环境中T淋巴细胞的功能与调控机制

Function and regulatory mechanism of T lymphocytes in tumor immune microenvironment of hepatocellular carcinoma

T淋巴细胞作为肿瘤免疫微环境中主要免疫细胞,能够通过产生细胞因子、细胞毒性酶(穿孔素、颗粒酶B)等途径影响肝癌细胞增殖、迁移从而控制肿瘤进展。同时,肿瘤免疫微环境中树突状细胞、髓样抑制细胞等免疫细胞可通过多种途径调控不同亚型T淋巴细胞的功能。本文综述了肿瘤免疫微环境中常见免疫细胞对T淋巴细胞功能的影响,以及涉及T淋巴细胞功能调节的关键信号通路在HCC中的作用机制,以期为HCC更优治疗策略的研发提供思路和线索。

As the key immune cells in tumor immune microenvironment,T lymphocytes can affect the proliferation and migration of hepatocellular carcinoma(HCC)cells and control tumor progression through the secretion of cytokines,cytotoxic enzymes(perforin,granzyme B),and other pathways.At the same time,immune cells such as dendritic cells and myeloid-derived suppressor cells in tumor immune microenvironment can regulate the immune function of different T cell subsets through various pathways.This article summarizes the influence of common immune cells in tumor immune microenvironment on the function of T lymphocytes and the mechanism of action of key signaling pathways associated with the functional regulation of T lymphocytes in HCC,so as to provide ideas and clues for developing better therapeutic strategies for HCC.