骨髓间充质干细胞及其外泌体治疗终末期肝病的研究进展

Research advances in bone marrow mesenchymal stem cells and its exosomes in treatment of end-stage liver disease

终末期肝病是各种急慢性肝病的晚期阶段,病死率高,严重危害人民健康。目前有效的治疗方法是肝移植,但囿于供体短缺、费用高昂等因素极大地限制了其临床应用。近年来临床与基础研究表明,骨髓间充质干细胞及其外泌体在治疗终末期肝病上具有良好的临床应用前景。本文就骨髓间充质干细胞及其外泌体在终末期肝病治疗中的作用机制与临床应用研究概况作一综述,期冀为进一步研究提供参考。

End-stage liver disease is the late stage of various acute and chronic liver diseases with high mortality and seriously threatens people’s health.Liver transplantation is currently an effective treatment method for this disease,but its clinical application is greatly limited by the factors such as shortage of donors and high costs.In recent years,clinical and basic studies have shown that bone marrow mesenchymal stem cell and its exosomes have good clinical application prospects in the treatment of end-stage liver disease.This article reviews the mechanism of action and clinical application of bone marrow mesenchymal stem cell and its exosomes in the treatment of end-stage liver disease,so as to provide a reference for further research.