竞争性内源RNA在胆管细胞癌发生发展中的作用

The role of competitive endogenous RNA in the development of cholangiocarcinoma

竞争性内源RNA是能够竞争性结合miRNA的一类转录产物,主要包括长链非编码RNA及环状RNA等,参与多种肿瘤的发生过程。胆管癌恶性程度高,预后差,治疗手段有限,发病机制复杂。竞争性内源RNA,特别是长链非编码RNA和环状RNA,能够通过影响胆管癌细胞的生物学行为、细胞代谢、炎症过程、上皮-间质转化过程影响胆管癌的发生发展。本文对长链非编码RNA与环状RNA在胆管细胞癌发生中的作用进行综述,以期进一步阐明胆管癌的发病机制。

Cholangiocarcinoma is a highly malignant tumor with a poor prognosis,limited treatment options,and complicated pathogenesis.Competitive endogenous RNA is a kind of transcripts that can competitively bind miRNA,including long non-coding RNA and circular RNA.Competitive endogenous RNA is known to be involved in a variety of tumors.It can modulate the occurrence and development of cholangiocarcinoma by regulating the biological behavior,cell metabolism,inflammatory process and epithelial-mesenchymal transition of cholangiocarcinoma cells.Here we review recent research progress on the role of long non-coding RNA and circular RNA in cholangiocarcinoma to help better understand the pathogenesis of cholangiocarcinoma.