药物诱导的肠道黏膜损伤

Drug-induced Intestinal Mucosal Injury

许多药物具有胃肠道黏膜损伤的不良反应,在药物治疗期间,一旦出现原发胃肠道疾病加重或出现新的胃肠道症状,应考虑由药物引起的可能性,及时行消化道内镜检查可明确诊断。本文对临床常见的非甾体抗炎药、化疗药物、免疫检查点抑制剂和抗菌药物相关肠道黏膜损伤的病因、发病机制以及临床诊治作一概述。

Drug-induced intestinal mucosal injury is a commonly seen adverse event with the exposure to various drugs.During the course of drug therapy,when exacerbation of primary gastrointestinal disease or new onset of gastro-intestinal symptoms occurs,drug-induced injury should be considered.Patients should be evaluated by gastrointestinal endoscopy for confirming the diagnosis.In this article,the etiologic and pathogenic factors,as well as the diagnostic and therapeutic approaches of four commonly seen drug-induced intestinal mucosal injuries,which were caused by nonsteroidal anti-inflammatory drugs,chemotherapeutic agents,immune checkpoint inhibitors and antibiotics were reviewed.