奥拉西坦联合甘露醇改善脑出血后脑水肿的效果观察

Effect Observation of Oxiracetam Combined with Mannitol inImproving Cerebral Edema After Cerebral Hemorrhage

目的观察奥拉西坦联合甘露醇治疗脑出血后脑水肿的临床效果。方法选取2020年3月-2021年3月在我院诊治的56例脑出血后脑水肿患者为研究对象,采用随机数字表法分为对照组和观察组,各28例。对照组采用甘露醇治疗,观察组在对照组基础上联合奥拉西坦治疗;比较两组临床疗效、脑水肿和脑血肿体积、神经功能缺损(NIHSS)评分、颅内压、日常生活活动能力(Bathel)评分及不良反应发生情况。结果观察组治疗总有效率为92.86%,高于对照组的82.14%(P<0.05);观察组脑水肿、脑血肿体积均小于对照组(P<0.05);两组NIHSS评分均低于治疗前,且观察组低于对照组(P<0.05);观察组颅内压低于对照组,Bathel评分高于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论奥拉西坦联合甘露醇治疗脑出血后脑水肿效果确切,可降低患者NIHSS、Bathel评分及颅内压,缩小脑水肿和脑血肿体积,且不良反应少,是一种安全有效的治疗方案。

Objective To observe the clinical effect of oxiracetam combined with mannitol in the treatment of cerebral edema after cerebral hemorrhage.Methods A total of 56 patients with cerebral edema after cerebral hemorrhage diagnosed and treated in our hospital from March 2020 to March 2021 were selected as the research objects.They were divided into control group and observation group by random number table method,with 28 cases in each group.The control group was treated with mannitol,and the observation group was treated with oxiracetam on the basis of the control group.The clinical efficacy,cerebral edema and hematoma volume,neurological deficit score(NIHSS),intracranial pressure,activity of daily living(Bathel)score and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 92.86%,which was higher than 82.14%in the control group(P<0.05).The volume of cerebral edema and cerebral hematoma in the observation group was smaller than that in the control group(P<0.05).The NIHSS scores of the two groups were lower than those before treatment,and the observation group was lower than the control group(P<0.05).The intracranial pressure of the observation group was lower than that of the control group,and the Bathel score was higher than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Oxiracetam combined with mannitol is effective in the treatment of cerebral edema after cerebral hemorrhage,which can reduce NIHSS,Bathel score and intracranial pressure,reduce cerebral edema and cerebral hematoma volume,and has fewer adverse reactions.It is a safe and effective treatment.