膳食营养对阿尔兹海默症机制的调控作用

Regulatory effect of dietary nutrients on the pathogenesis of Alzheimer′s disease

阿尔兹海默症(Alzheimer′s disease,AD)又称老年痴呆,是一种进行性的神经退行性疾病,患者主要临床表现为记忆力减退、认知功能障碍、行为异常和社交障碍等。目前AD并没有有效的治疗手段,所以早期防控尤其重要。自古以来,中医药里就用“药食同源”的理论使用食补防治疾病的进展,合理膳食在AD早期防控中占重要位置。文章主要从日常常见的植物多酚、维生素、脂肪酸对AD发病机制的影响进行综述,以期明确膳食营养素在AD早期防控中的作用,为调整膳食结构改善大脑健康提供理论支撑。

Alzheimer′s disease(AD),also known as dementia,is a progressive neurodegenerative disease.The main clinical manifestations of AD patients are memory loss,cognitive dysfunction,abnormal behavior and social impairment.At present,there is no effective treatment available for AD,so early prevention and control is particularly important.Since ancient times,the theory of"medicine and food are of the same origin"has existed in traditional Chinese medicine,therefore,a variety of food supplements have been used in the intervention and control of the progress of various diseases.Reasonable diet plays an important role in the early prevention and control of AD.This paper mainly reviews the effects of common plant polyphenols,vitamins,and fatty acids on the pathogenesis of AD,in order to clarify the role of dietary nutrients in the early prevention and control of AD,and to provide theoretical support for adjusting the dietary structure to improve brain health.