阿托伐他汀辅助治疗老年脑血栓的临床疗效分析

Clinical efficacy of atorvastatin in adjuvant treatment of cerebral thrombosis in the elderly

目的 分析阿托伐他汀辅助治疗老年脑血栓的临床疗效。方法 200例老年脑血栓患者,根据治疗方法的不同分为研究组及对照组,各100例。对照组采用常规溶栓治疗,研究组在对照组基础上采用阿托伐他汀辅助治疗。比较两组患者治疗前后的凝血指标(红细胞沉降率、血浆粘度、血小板粘附率)、神经功能缺损评分及生活能力评分。结果 治疗后,两组患者红细胞沉降率、血浆粘度、血小板粘附率均较本组治疗前降低,且研究组患者红细胞沉降率、血浆粘度、血小板粘附率分别为(21.82±4.14)mm/h、(1.03±0.62)mPa·s、(38.32±4.45)%,低于对照组的(27.75±6.53)mm/h、(1.95±0.52)mPa·s、(42.62±4.52)%,差异有统计学意义(P<0.05)。治疗后,两组患者神经功能缺损评分均较本组治疗前降低,且研究组患者神经功能缺损评分(6.38±0.56)分低于对照组的(8.86±0.62)分,差异有统计学意义(P<0.05)。治疗后,两组患者生活能力评分均较本组治疗前升高,且研究组患者生活能力评分(77.38±1.11)分高于对照组的(70.06±3.12)分,差异有统计学意义(P<0.05)。结论 对老年脑血栓患者实施阿托伐他汀辅助治疗可以有效改善患者凝血功能和神经功能缺损程度,提升患者的生活能力,临床可以考虑加以推广应用。

Objective To analyze the clinical efficacy of atorvastatin in adjuvant treatment of cerebral thrombosis in the elderly.Methods A total of 200 elderly patients with cerebral thrombosis were divided into research group and control group according to different treatment methods,with 100 cases in each group.The control group received conventional thrombolytic therapy,and the research group received atorvastatin adjuvant therapy on the basis of the control group.The coagulation indexes(erythrocyte sedimentation rate,plasma viscosity,platelet adhesion rate),neurological deficit score and activities of daily living score before and after treatment were compared between the two groups.Results After treatment,the erythrocyte sedimentation rate,plasma viscosity and platelet adhesion rate in the two groups were all lower than those before treatment in this group;the erythrocyte sedimentation rate,plasma viscosity,and platelet adhesion rate in the research group were(21.82±4.14)mm/h,(1.03±0.62)mPa·s,and(38.32±4.45)%,which were lower than(27.75±6.53)mm/h,(1.95±0.52)mPa·s,and(42.62±4.52)%in the control group;the differences were all statistically significant(P<0.05).After treatment,the neurological deficit scores of the two groups were lower than those of this group before treatment,and the neurological deficit score(6.38±0.56)points of the research group were lower than(8.86±0.62)points of the control group,and the differences were statistically significant(P<0.05).After treatment,the activities of daily living score of the two groups were higher than those of this group before treatment,and the activities of daily living score(77.38±1.11)points in the research group was higher than(70.06±3.12)points in the control group,and the differences were statistically significant(P<0.05).Conclusion The implementation of atorvastatin adjuvant therapy for elderly patients with cerebral thrombosis can effectively improve the coagulation function and neurological deficit degree of patients,and enhance the activities of daily living of patients,which can be considered for clinical promotion and application.