盐酸托莫西汀治疗儿童注意缺陷多动障碍伴抽动障碍的疗效探讨

Discussion on the efficacy of atomoxetine hydrochloride in the treatment of children with attention-deficit hyperactivity disorder and tic disorder

目的 研究盐酸托莫西汀治疗儿童注意缺陷多动障碍伴抽动障碍的疗效。方法 96例注意缺陷多动障碍伴抽动障碍患儿,依据治疗方式不同分为实验组和对照组,每组48例。两组患儿均给予心理及行为干预,在此基础上,对照组采用盐酸哌甲酯治疗,实验组采用盐酸托莫西汀治疗。对比两组患儿的不良反应发生率、Conners父母用评定问卷(PSQ)评分。结果 实验组患儿的不良反应发生率6.25%(3/48)低于对照组的20.83%(10/48),差异具有统计学意义(P<0.05)。干预后,实验组患儿PSQ的品行问题、学习问题、心身障碍、冲动多动、焦虑、多动指数评分分别为(0.57±0.51)、(0.44±0.34)、(0.33±0.54)、(0.31±0.18)、(0.24±0.11)、(0.29±0.48)分,均低于对照组的(0.84±0.11)、(0.77±0.81)、(0.54±0.21)、(0.62±0.82)、(0.39±0.24)、(0.52±0.62)分,差异具有统计学意义(P<0.05)。结论 注意缺陷多动障碍伴抽动障碍患儿采用盐酸托莫西汀进行治疗的临床疗效更加显著,可以有效提高患儿的注意力,纠正患儿的多动症状,并且使其抽动症状的发生频率得到缓解,且治疗后的不良反应比较少,安全性更高。

Objective To study the efficacy of atomoxetine hydrochloride in the treatment of children with attention-deficit hyperactivity disorder and tic disorder.Methods A total of 96 children with attentiondeficit hyperactivity disorder and tic disorder were divided into experimental group and control group according to different treatment methods,with 48 cases in each group.Both groups were given psychological and behavioral intervention.On this basis,the control group was treated with methylphenidate hydrochloride,and the experimental group was treated with atomoxetine hydrochloride.The incidence of adverse reactions and the Parent Symptom Questionnaire(PSQ)score were compared between the two groups.Results The incidence of adverse reactions 6.25%(3/48)in the experimental group was lower than 20.83%(10/48)in the control group,and the difference was statistically significant(P<0.05).After intervention,the the scores of conduct problems,learning problems,psychosomatic disorders,impulsive hyperactivity,anxiety and hyperactivity index of the PSQ in the experimental group were(0.57±0.51),(0.44±0.34),(0.33±0.54),(0.57±0.51),(0.44±0.34),(0.33±0.54),(0.31±0.18),(0.24±0.11)and(0.29±0.48)points,which were lower than(0.84±0.11),(0.77±0.81),(0.54±0.21),(0.62±0.82),(0.39±0.24)and(0.52±0.62)points in the control group,and the differences were all statistically significant(P<0.05).Conclusion Atomoxetine hydrochloride is more effective in the treatment of children with attention deficit hyperactivity disorder and tic disorder,which can effectively improve the child's attention,correct the child's hyperactivity symptoms,and alleviate the frequency of tic symptoms,with fewer adverse reactions after treatment and higher safety.