中药活血行气汤用于老年气滞血瘀型冠心病心绞痛治疗中的药理价值体会

Pharmacological value of traditional Chinese medicine Huoxue Xingqi Decoction in the treatment of angina pectoris of coronary heart disease with qi stagnation and blood stasis syndrome in the elderly

目的 探究老年气滞血瘀型冠心病心绞痛患者给予中药活血行气汤的疗效及药理价值。方法 80例老年气滞血瘀型冠心病心绞痛患者,采用随机数字表法分为观察组与对照组,每组40例。对照组给予西药治疗,观察组采用中药活血行气汤治疗。比较两组临床疗效、治疗前后的心功能指标及血液流变学指标。结果 观察组治疗总有效率为97.50%,高于对照组的85.00%,差异有统计学意义(P<0.05)。治疗后,两组左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)均小于治疗前,左室射血分数(LVEF)高于治疗前,且观察组LVESD(37.36±2.62)mm、LVEDD(44.51±2.42)mm小于对照组的(42.02±2.10)、(50.42±4.03)mm,LVEF(48.72±5.03)%高于对照组的(39.64±4.33)%,差异有统计学意义(P<0.05)。治疗后,两组红细胞压积、全血高切粘度、血浆粘度均低于治疗前,且观察组红细胞压积(0.42±0.04)、全血高切粘度(5.61±0.32)mPa·s、血浆粘度(1.72±0.13)mPa·s均低于对照组的(0.61±0.08)、(10.32±0.53)mPa·s、(2.24±0.33)mPa·s,差异有统计学意义(P<0.05)。结论 使用中药活血行气汤治疗老年气滞血瘀型冠心病心绞痛患者临床疗效确切,可有效改善患者心功能指标及血液流变学指标,具有很高的药用价值。

Objective To investigate the efficacy and pharmacological value of traditional Chinese medicine Huoxue Xingqi Decoction in the treatment of angina pectoris of coronary heart disease with qi stagnation and blood stasis syndrome in the elderly.Methods A total of 80 elderly patients with angina pectoris of coronary heart disease with qi stagnation and blood stasis syndrome were divided into observation group and control group by random numerical table,with 40 cases in each group.The control group was treated with western medicine,and the observation group was treated with traditional Chinese medicine Huoxue Xingqi Decoction.The clinical efficacy,cardiac function indexes and hemorheology indexes before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 97.50%,which was higher than 85.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD)in both groups were smaller than those before treatment in this group,and left ventricular ejection fraction(LVEF)was higher than that before treatment in this group;the LVESD(37.36±2.62)mm and LVEDD(44.51±2.42)mm in the observation group were smaller than(42.02±2.10)and(50.42±4.03)mm in the control group;the LVEF(48.72±5.03)%in the observation group was higher than(39.64±4.33)%in the control group;the differences were all statistically significant(P<0.05).After treatment,the hematocrit,whole blood high shear viscosity and plasma viscosity in both groups were lower than those before treatment in this group;the hematocrit(0.42±0.04),whole blood high shear viscosity(5.61±0.32)mPa·s and plasma viscosity(1.72±0.13)mPa·s in the observation group were all lower than(0.61±0.08),(10.32±0.53)mPa·s and(2.24±0.33)mPa·s in the control group;the differences were all statistically significant(P<0.05).Conclusion Traditional Chinese medicine Huoxue Xingqi Decoction has definite clinical efficacy in the treatment of angina pectoris of coronary heart disease with qi stagnation and blood stasis syndrome in the elderly,and can effectively improve the cardiac function indexes and hemorheology indexes of patients,which contains high pharmacological value.