左西孟旦联合注射用重组人脑利钠肽治疗慢性心力衰竭急性发作患者的效果

Effects of Levosimendan combined with recombinant human brain natriuretic peptide for injection in treatment of patients with acute attack of chronic heart failure

目的:观察左西孟旦联合注射用重组人脑利钠肽(rh-BNP)治疗慢性心力衰竭急性发作患者的效果。方法:选取2018年1月至2020年1月该院收治的120例慢性心力衰竭急性发作期患者进行前瞻性研究,按照随机数字表法分为观察组与对照组各60例。两组均给予常规吸氧、利尿、强心等治疗,在此基础上,对照组给予注射用rh-BNP治疗,观察组在对照组基础上联合左西孟旦治疗,比较两组临床疗效、心功能指标[左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)及血浆脑钠肽(BNP)]水平和炎性指标[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)]水平。结果:观察组治疗总有效率为98.33%,明显高于对照组的86.67%,差异有统计学意义(P<0.05);治疗后,两组LVEDD、BNP水平均低于治疗前,且观察组低于对照组,两组LVEF水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组hs-CRP、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:左西孟旦联合注射用rh-BNP治疗慢性心力衰竭急性发作患者可提高治疗总有效率,改善心功能指标水平,以及降低炎性指标水平,效果优于单纯注射用rh-BNP治疗。

Objective:To observe effects of Levosimendan combined with recombinant human brain natriuretic peptide(rh-BNP)for injection in treatment of patients with acute attack of chronic heart failure.Methods:A prospective study was conducted on 120 patients with acute attack of chronic heart failure admitted to the hospital from January 2018 to January 2020.They were divided into observation group and control group according to the random number table method,60 cases in each.Both groups were given conventional oxygen,diuretic,cardiac treatment.On this basis,the control group was treated with rh-BNP for injection,while the observation group was treated with Levosimendan on the basis of that of the control group.The clinical efficacy,the cardiac function index levels[left ventricular end diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),plasma brain natriuretic peptide(BNP)],and the inflammatory index levels[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor alpha(TNF-α)]were compared between the two groups.Results:The total effective rate of treatment in the observation group was 98.33%,which was significantly higher than 86.67%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of LVEDD and BNP in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the LVEF levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of hs-CRP and TNF-αin the two groups were lower than those before the treatment,those of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).Conclusions:Levosimendan combined with rh-BNP for injection in the treatment of the patients with acute attack of chronic heart failure can improve the total effective rate of treatment,improve the levels of cardiac function indexes,and reduce the levels of inflammatory indexes.Moreover,it is superior to single rh-BNP for injection treatment.