术中快速冰冻病理检查在子宫内膜癌患者中的应用价值

Application value of intraoperative fast frozen pathological examination in endometrial carcinoma surgery

目的:探讨术中快速冰冻病理检查在子宫内膜癌患者中的应用价值。方法:选取2016年1月至2019年12月该院收治的88例子宫内膜癌患者进行前瞻性研究,术中均行快速冰冻病理检查,术后将其子宫病理标本做石蜡切片进行病理检查,比较两种检查方法诊断子宫内膜癌的准确性。结果:术中快速冰冻病理检查检出80例子宫内膜癌,诊断准确率为90.91%,漏诊率为9.09%。术中快速冰冻病理检查对子宫内膜癌G3级患者的检出率最高,为100.00%;对G2级患者的检出率为96.67%;对G1级患者的检出率最低,为81.58%,G1级、G2级、G3级检出率比较,差异有统计学意义(P<0.05)。术中快速冰冻病理检查对子宫内膜癌病变浸润Ⅲ期患者中的检出率最高,为100.00%;对Ⅱ期患者的检出率为96.88%;对Ⅰ期患者的检出率最低,为80.00%,Ⅰ期、Ⅱ期、Ⅲ期检出率比较,差异有统计学意义(P<0.05)。结论:术中快速冰冻病理检查诊断恶性级别较高的子宫内膜癌患者准确性较高,对低级别病变的诊断准确性较低。

Objective: To explore application value of intraoperative fast frozen pathological examination in endometrial carcinoma surgery. Methods: A prospective study was conducted on 88 patients with endometrial carcinoma;who were admitted to this hospital from January 2016 to December 2019. Intraoperative fast frozen pathological examination was performed. The uterine pathological samples were embedded in paraffin for pathological examination after the surgery. The accuracies of the two examination methods in the diagnosis of endometrial carcinoma were compared. Results: Intraoperative fast frozen pathological examination showed: a total of 80 cases were diagnosed with endometrial carcinoma, the diagnostic accuracy rate was 90.91%, the missed diagnosis rate was 9.09%. The diagnostic coincidence rate of intraoperative rapid frozen pathological examination was the highest in patients with endometrial carcinoma G3(100.00%);The detection rate of G2 grade patients was 96.67%;The detection rate of G1 was the lowest(81.58%). The detection rate of G1, G2 and G3 was statistically significant(P<0.05). The detection rate of intraoperative rapid frozen pathological examination was the highest in patients with endometrial carcinoma infiltration grade III, which was 100.00%;The detection rate in grade ⅱ patients was 96.88%;The detection rate was the lowest in grade I patients(80.00%). The detection rate of grade I, II and III was statistically significant(P<0.05). Conclusions: The diagnostic accuracy of intraoperative rapid frozen pathological examination increase with the increase of tumor grade and the deepening of lesion infiltration.