应用血滤机治疗尿毒症合并急性呼吸窘迫综合征疗效观察

Effect of Hemofiltration on Uremia Complicated with Acute Respiratory Distress Syndrome

目的:研究血滤机治疗尿毒症合并急性呼吸窘迫综合征的临床疗效。方法:选取本院收治的42例尿毒症合并急性呼吸窘迫综合征患者为研究对象,应用随机数字表法将患者分为两组,对照组采用常规治疗,研究组在对照组治疗基础上应用血滤机进行连续性血液净化治疗。观察两组患者治疗前后的炎症因子、血流动力学指标和生化指标。结果:治疗前两组患者降钙素原和C反应蛋白指标差异均无统计学意义(P>0.05),治疗后研究组的降钙素原和C反应蛋白均显著低于对照组(P<0.05)。治疗前两组患者的心率、中心静脉压和平均动脉压差异均无统计学意义(P>0.05),治疗后研究组的心率、中心静脉压和平均动脉压均显著优于对照组(P<0.05)。治疗前两组患者血钾离子、血尿素氮和血肌酐指标差异均无统计学意义(P>0.05),治疗后研究组的血钾离子、血尿素氮和血肌酐均显著低于对照组(P<0.05)。结论:血滤机治疗有助于改善尿毒症合并急性呼吸窘迫综合征患者的治疗效果。

Objective:To study the clinical efficacy of hemofiltration in the treatment of uremia complicated with acute respiratory distress syndrome.Methods:42 patients with uremia and acute respiratory distress syndrome were selected and randomly divided into two groups.The control group was treated with routine treatment,and the study group was treated with continuous blood purification with blood filter on the basis of the control group.The inflammatory factors and biochemical indexes of the two groups before and after treatment were observed.Results:There was no significant difference in the indexes of procalcitonin and C-reactive protein between the two groups before treatment(P>0.05).After treatment,the indexes of procalcitonin and C-reactive protein in the study group were significantly lower than those in the control group(P<0.05).There was no significant difference in heart rate,central venous pressure and mean arterial pressure between the two groups before treatment(P>0.05).After treatment,the heart rate,central venous pressure and mean arterial pressure of the study group were significantly better than those of the control group(P<0.05).There was no significant difference in blood potassium ion,blood urea nitrogen and blood creatinine between the two groups before treatment(P>0.05).After treatment,the blood potassium ion,blood urea nitrogen and blood creatinine in the study group were significantly lower than those in the control group(P<0.05).Conclusion:Hemofiltration is helpful to improve the therapeutic effect of uremia complicated with acute respiratory distress syndrome.