吗替麦考酚酯致踝关节疼痛1例

A case of ankle pain caused by mycophenolate mofetil

1例72岁男性患者,诊断为免疫相关性脑炎。2021年7月14日患者脑炎二次复发后开始服用吗替麦考酚酯(MMF)抗免疫治疗,给药日剂量由1 g逐渐增加至2 g,剂量增加后1周,患者出现不明原因的踝关节疼痛、水肿,对症给予硫酸镁外敷和红外线局部照射后缓解。在维持MMF给药日剂量为2 g的过程中,患者踝关节疼痛、水肿持续存在。调整MMF日剂量为1.5 g,治疗的第6天,关节疼痛、水肿症状逐渐缓解并痊愈,患者在院期间未再发生类似情况。

A 72-year-old male patient was diagnosed with immune-related encephalitis.On July 1.4th,2021,he began to take mycophenolate mofetil(MMF)for anti-immune treatment after the second recurrence of encephalitis.The daily dose of MMF was gradually increased from 1 g to 2 g.One week after the dose increase,he developed unexplained ankle pain and edema,which was relieved after symptomatic treatment including external application of magnesium sulfate,infrared ray radiation.During the course of maintaining treatment of MMF with the daily dose of 2 g,the pain and edema of the ankle joint persisted.On the 6th day after the daily dose of MMF was reduced to 1.5 g,the above symptoms gradually relieved.The patient did not experience similar conditions again during the hospital period.