摘要
N^(6)-甲基腺苷(N^(6)-methyladenosine,m^(6)A)是一种动态的由甲基转移酶复合体、去甲基化酶以及结合蛋白作用产生的一种在生物体大量组织中存在的RNA表观遗传修饰,在多种生命过程中起到重要的调控作用。脂肪作为影响畜禽肉质评定的关键因素之一,其对于畜牧业的重要性不言而喻。本文概述了m^(6)A甲基化修饰和脂肪生成的基本过程,并总结了m^(6)A甲基化修饰影响脂肪生成的机制,以期为研究动物脂肪调控提供新思路。
N^(6)-methyladenine(N^(6)-methyladenosine, m^(6)A) is a kind of RNA epigenetic modification in a large number of tissues catalyzed by methyltransferase complex, demethylase and binding protein. It plays an important regulatory role in many life processes. As one of the key factors affecting the meat quality evaluation of livestock, the importance of fat for animal husbandry is self-evident. In this paper, we will summarize the basic process of m^(6)A methylation and adipogenesis, and discuss the relationship between them. We will review the mechanism of m^(6)A methylation on adipogenesis, hoping to provide new ideas for the study of animal fat regulation.
作者
宋兴亚
彭巍
刘贤
姚治
张子敬
雷初朝
王二耀
黄永震
SONG Xingya;PENG Wei;LIU Xian;YAO Zhi;ZHANG Zijing;LEI Chuzhao;WANG Eryao;HUANG Yongzhen(College of Animal Science and Technology,Northwest Agriculture and Forestry University,Shaanxi Yangling,712100,China;Qinghai Academy of Animal Science and Veterinary Medicine,Qinghai University,Qinghai Xining 810016,China;Henan Provincial Animal Husbandry General Station,Henan Zhengzhou450008,China;Institute of Animal Husbandry and Veterinary Science,Henan Academy of Agricultural Sciences,Henan Zhengzhou 450002,China)
出处
《中国畜牧杂志》
CAS
北大核心
2022年第10期53-58,共6页
Chinese Journal of Animal Science
基金
财政部与农业农村部-国家现代农业产业技术体系(CARS-37)
河南省肉牛产业技术体系(S2013-08)
河南省农业科学院科技创新创意项目(2020CX09)
河南省农业科学院优秀青年科技基金(2020YQ36)
西北农林科技大学2020年大学生创新创业训练计划项目(S202010712200)。
