高毒力肺炎克雷伯菌实验室鉴定方法的研究进展

Research progress on laboratory identification methods of hypervirulent Klebsiella pneumoniae

高毒力肺炎克雷伯菌(hypervirulent Klebsiella pneumoniae,hvKP)具有独特的表型特征和基因型特征,常导致严重的感染。然而,国际上仍无统一的hvKP定义标准,造成不同研究选择的hvKP评价方案不尽相同,基于流行病学分析和感染的快速诊断等多方需求,目前迫切需要关于hvKP的客观鉴定方法。本文从hvKP的表型、毒力基因、毒力评估方面对其实验室鉴定方法进行综述,希望对hvKP的防控提供参考。

Hypervirulent Klebsiella pneumoniae(hvKP)has unique phenotypic and genotypic characteristics,which often leads to serious infections.However,there is still no standard hvKP definition in the world,resulting in different hvKP evaluation schemes selected by different studies.Based on epidemiological analysis and rapid diagnosis of infection and other needs,objective identification methods of hvKP are urgently needed.This article reviews of laboratory identification methods of hvKP from its phenotype,virulence genes,and virulence assessment,desirable to provide a reference for the prevention and control of hvKP.