口服地芬尼多片中毒死亡9例

Forensic Analysis of 9 Poisoning Death Cases Caused by Oral Administration of Diphenidol

目的分析地芬尼多中毒案(事)例的特点,为此类案件的鉴定提供线索和技术手段。方法使用超高效液相色谱-串联质谱(ultra-high performance liquid chromatography-tandem mass spectrometry,UPLCMS/MS)法对9例地芬尼多中毒致死者的生物样本进行检测,并对案例特点进行回顾性分析。结果地芬尼多中毒死者以青年女性居多,服用剂量在60~300片,死后血液中地芬尼多的质量浓度范围为0.87~99.00μg/mL。服药剂量与血液中地芬尼多质量浓度无相关性。结论地芬尼多中毒具有高隐蔽性和致命性的特点,对于自杀案件应给予更多的关注,推荐将地芬尼多作为常规鉴定项目以防漏检。

Objective To analyze the characteristics of diphenidol poisoning cases and to provide clues and technical means for the identification of such cases.Methods Biological samples of 9 deaths caused by diphenidol poisoning were detected by ultra-high performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS),and the characteristics of these cases were analyzed retrospectively.Results Most of the deaths caused by diphenidol poisoning were young females.The dosage was between 60 and 300 tablets,and the mass concentration of diphenidol in the postmortem blood ranged from 0.87 to 99.00μg/mL.There was no correlation between the dosage and the concentration of diphenidol in the blood.Conclusion Diphenidol poisoning has the characteristics of high concealment and lethality.More attention should be paid to suicide cases,and diphenidol should be recommended as a routine detection item to avoid missing detection.