应用DUR和DUE评价大理市某医院青年缺血性脑卒中患者用药情况

Evaluation of the Drug Utilization of Young Patients with Cerebral Ischemic Stroke in a Hospital in Dali City by DUR and DUE

目的:评价大理大学第一附属医院2018—2020年青年缺血性脑卒中患者用药情况及用药合理性。方法:采用药物利用评价(DUR)和药物利用评估(DUE)评价患者使用药物种类、频次及合理性。结果:75例患者使用药物共13类61种,含西药48种和中药注射剂13种,其中调血脂药使用比例最高,达98.7%。DUR结果显示有11种药物的药物利用指数(DUI)>1,24种药物的DUI=1;26种药物的DUI<1。DUI>1的西药主要是抑酸药和降压药,DUI<1的药物种类广,多为联合用药减量所致。DUE结果显示,与药物相关的实验室检查指标监测率偏低,患者不良反应主要为胃肠道反应。经药物治疗后,74例患者临床症状有所改善。结论:该院青年缺血性脑卒中患者药物种类选择合理,但须加强抑酸药和降压药使用管理,同时加强治疗过程中对相关实验室检查指标及不良反应的监测。

Objective:To evaluate the drug utilization and rationality of young patients with cerebral ischemic stroke in the First Affiliated Hospital of Dali University from 2018 to 2020. Methods:Drug utilization review(DUR) and drug utilization evaluation(DUE)were used to evaluate the type,frequency and rationality of drugs used by patients. Results:61 drugs in 13 categories were applied in the treatment of 75 patients,including 48 western drugs and 13 traditional Chinese medicine injections,among which the proportion of lipid-regulating drugs was the highest,reaching 98.7%. DUR results showed that the drug utilization index(DUI)of 11 drugs was greater than 1,the DUI of 24 drugs was 1,and the DUI of 26 drugs was less than 1. Western drugs with DUI greater than 1 were mainly acid inhibitor and antihypertensive drugs,while drugs with DUI less than 1 were of a wide variety,mostly caused by dose reduction in combination drugs. DUE results showed that the monitoring rate of drug-related laboratory test indicators was low,and the main adverse reactions were gastrointestinal reactions. After drug treatment,the clinical symptoms of 74 patients were improved. Conclusion:The selection of drugs for young patients with cerebral ischemic stroke in this hospital is reasonable,but it is necessary to strengthen the management of acid inhibitor and antihypertensive drugs,and strengthen the monitoring of related laboratory indicators and adverse reactions during treatment.