摘要
赖氨酰氧化酶(LOX)家族由LOX和4种LOX样蛋白(LOXL1~4)组成,主要作用于细胞外基质的重塑以及胶原蛋白和弹性蛋白的交联。胃癌是发展中国家中发病率较高的消化系统恶性肿瘤之一,病死率在所有恶性肿瘤中排第3位。越来越多的研究表明,LOX家族蛋白与胃癌细胞增殖、迁移、侵袭和转移的调节密切相关。现就LOX家族各个成员与胃癌发生和发展的关系作一综述,以期发现可用于胃癌治疗的LOX家族蛋白质成员的特异性抑制剂。
The lysyl oxidase(LOX)family consists of LOX and 4 types of LOX-like proteins(LOXL1-4),and it mainly acts on the remodeling of the extracellular matrix and cross-linking of collagen and elastin. Gastric cancer is one of the digestive system cancers with high incidence in developing countries,and its mortality rate is the third place among all cancers. More and more studies have shown that the LOX family proteins are closely related to the regulation of gastric cancer cell proliferation,migration,invasion and metastasis. This article reviews the relationship between each member of LOX family and the occurrence and development of gastric cancer,with a view to finding specific inhibitors of LOX family protein members that can be used in the treatment of gastric cancer.
作者
熊伟
李彬
王播勇
刘如爱
姜北
自加吉
周静华
Xiong Wei;Li Bin;Wang Boyong;Liu Ruai;Jiang Bei;Zi Jiaji;Zhou Jinghua(Pre-clinical College,Dali University,Dali,Yunnan 671000,China;Key Laboratory of Clinical Biochemistry of Yunnan Province,Dali,Yunnan 671000,China;Yunnan Provincial Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan,Dali,Yunnan 671000,China)
出处
《大理大学学报》
2022年第10期75-80,共6页
Journal of Dali University
基金
国家自然科学基金项目(31760331,32160167,82160516)
云南省李云庆专家工作站项目(202005AF150014)
云南省高校病理学与病理生理学硕士研究生导师团队项目(2019028)
云南省教育厅科学研究基金项目(2020J0566)。
关键词
赖氨酰氧化酶家族
细胞外基质
胃癌
发生发展
lysyl oxidase family
extracellular matrix
gastric cancer
occurrence and development
