2-乙基-2-芳基-二氢喹啉衍生物的合成

Synthesis of 2‐Ethyl‐2‐Aryl‐Dihydroquinoline Derivatives

研究了2-乙基-2-芳基-二氢喹啉衍生物的合成方法。合成分成三步:第一步,2-溴喹啉与苯硼酸进行Suzuki交叉偶联;第二步,进行卤锂交换;第三步,有机锂试剂在2-苯基喹啉的α位进行亲核加成,得到双取代二氢喹啉衍生物。通过此方法合成了具有二氢喹啉结构的药物,并通过各种表征手段对目标产物进行了分析,确认了目标产物的结构。

The synthesis method of 2‐ethyl‐2‐aryl‐dihydroquinoline derivatives was studied.The synthesis is divided into three steps:the first step,the Suzuki cross‐coupling of 2‐bromoquinoline and phenylboronic acid;the second step,the exchange of halide lithium;the third step,the nucleophilic addition of the organolithium reagent to theα‐position of 2‐phenylquinoline to obtain a double‐substituted dihydroquinoline derivative.The drug with dihydroquinoline structure was synthesized by this method,and the target product was analyzed by various characterization methods,and the structure of the target product was confirmed.