血脂异常与胃癌发生关系的研究进展

Research progress on the relationship between dyslipidemia and gastric cancer

随着饮食习惯的改变,血脂紊乱发生率亦显著上升。血脂异常不仅作为一系列代谢性疾病的特征性表现,同时其亦是包括胃癌在内的多种疾病的重要危险因素。多数癌症患者中常存在血脂异常的情况,而脂质代谢水平的紊乱可能伴随着更高的肿瘤发病风险,因此合理使用降脂药物对于血脂异常本身甚至癌症的预防均有一定的作用。文章回顾和分析了当前有关血脂异常和胃癌发生的相关研究,主要就血脂异常和其可能的致癌机制、与胃癌发病的相关性以及调脂药物在胃癌患者中的应用进展进行综述。

The incidence of dyslipidemia has been increasing significantly as the change of dietary habits.Dyslipidemia serves as a hallmark manifestation of a range of metabolic diseases and an important risk factor for a variety of diseases such as stomach cancer.Dyslipidemia occurs in many of cancers,whereas the disturbance of lipid metabolism level may be associated with a higher risk of tumorigenesis.Consequently,the appropriate use of lipid-lowering agents may potentially play a role in the prevention of dyslipidemia and possibly even cancer.In this review,we analyzed the current studies on dyslipidemia and gastric carcinogenesis,with the aim of elucidating dyslipidemia and possible carcinogenic mechanisms,the correlation with gastric carcinogenesis,and the application of lipid-regulating agents in the patients with gastric cancer.