体育锻炼抵御COVID-19发生、发展的作用与可能分子机制

Role and Possible Molecular Mechanism of Physical Exercise in Resisting the Occurrence and Development of COVID-19

2019冠状病毒病(Coronavirus Disease 2019,COVID-19)于2019年12月暴发以来仍在全球迅速传播,感染和死亡人数还在不断增长。由于COVID-19的症状广泛、患者人群复杂,故开发特定的临床药物尚需一定的时间,需要有其他预防或辅助应对COVID-19的干预策略。根据体育锻炼抗病毒的分子机制及严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)的致病机理,从体育锻炼提高细胞免疫功能、增强机体抗氧化防御能力、改善病毒诱发的铁代谢障碍和内皮功能障碍等方面,探析体育锻炼在抵御SARS-CoV-2入侵、延缓病情发展、降低重症发生率、减少患者并发症中的可能作用,为倡导全民参加体育锻炼积极应对COVID-19提供生理学依据。

Since its initial outbreak in December 2019,coronavirus disease 2019(COVID-19)has rapidly spread worldwide,with the number of infections and deaths continuing to surge.However,due to its wide range of symptoms and clinical difference of patients,it takes time to develop specific clinical drugs,therefore,other intervention strategies that can prevent and auxiliarily treat COVID-19 is needed.On the basis of the molecular mechanism of physical exercise's antiviral function and the pathogenesis of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the potential role of physical exercise is discussed in resisting SARS-CoV-2 infection,delaying the disease development,reducing severe disease incidence,and decreasing patient complications via improving cellular immune function,enhancing antioxidant defense ability,and improving endothelial dysfunction induced by virus and iron metabolism.Thus,a physiological basis is provided for advocating and promoting active participation in physical exercise to resist COVID-19.