宫内感染早产儿血清神经元特异性烯醇化酶(NSE)、S100B蛋白、肌酸激酶(CK)水平的变化与其脑损伤的关系分析

Analysis of the Relationship between Changes in Serum Neuron Specific Enolase(NSE),S100B Protein,and Creatine Kinase(CK)Levels in Intrauterine Infected Preterm Infants and their Brain Damage

目的分析宫内感染早产儿血清神经元特异性烯醇化酶(NSE)、S100B蛋白、肌酸激酶(CK)水平的变化与其脑损伤的关系。方法回顾性分析2012年2月至2020年12月期间开封某医院收治的114例宫内感染早产儿的临床资料,比较合并脑损伤组与未合并脑损伤组患儿血清神经元特异性烯醇化酶(NSE)、S100B蛋白、肌酸激酶(CK)水平,比较脑损伤组内不同程度脑损伤患儿相关指标的变化。结果合并脑损伤组与未合并脑损伤组患儿性别、胎龄、出生体质量、分娩方式无显著差异(P>0.05)。2组患儿自出生后24h至120h血清中NSE、S100B蛋白、CK水平呈现降低趋势(P<0.05或P<0.01),且合并脑损伤组患儿血清中NSE水平、出生后24h、72h、120h时S100B蛋白、CK水平均显著高于未合并脑损伤组患儿(P<0.05或P<0.01)。合并脑损伤患儿随着脑损伤程度的不断升高,其血清中NSE、S100B蛋白、CK水平呈现显著升高趋势(P<0.05)。结论宫内感染早产儿发生脑损伤后血清中NSE、S100B蛋白、CK水平显著高于未发生脑损伤患儿,且脑损伤程度越高者上述指标水平越高。

Objective To analyze the relationship between the changes of serum neuron specific enolase(NSE),S100B protein,creatine kinase(CK)and brain injury in intrauterine infected preterm infants and their brain damage.Methods The clinical data of 114 premature infants with intrauterine infection treated in a hospital in Kaifeng from February 2012 to December 2020 were analyzed retrospectively,the serum levels of neuron-specific enolase(NSE),S100B protein,and creatine kinase(CK)between the children with combined brain injury group and the children without combined brain injury group were compared,the changes of relevant indicators of children with different degrees of brain injury in the brain injury group were compared.Results There were no significant differences in gender,gestational age,birth quality and delivery mode between the combined and uncombined brain injury groups(P>0.05);The serum levels of NSE,S100B protein and CK in 2 groups decreased from 24 hours to 120 hours after birth(P<0.05 or P<0.01),The levels of serum NSE,S100B protein and CK at 24h,72h and 120h after birth in the group with brain injury were significantly higher than those in the group without brain injury(P<0.05 or P<0.01),With the increasing degree of brain injury,the levels of NSE,S100B protein and CK in serum increased significantly(P<0.05).Conclusion The serum levels of NSE,S100B protein and CK in preterm infants with intrauterine infection after brain injury were significantly higher than those in children without brain injury,and the higher the degree of brain injury,the higher the above index level.